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Crit Rev Microbiol:肽聚糖水解酶在结核发病机制中的认识

2017-03-27 MedSci MedSci原创

目前,结核病仍是威胁人类健康的主要疾病之一,全球有20-30亿人感染结核分支杆菌,形式十分严峻。有效阻断潜伏性结核感染转变为活动性的结核至关重要。近期,Crit Rev Microbiol杂志中的一篇文章介绍了肽聚糖水解酶在结核分支杆菌及放线菌的复苏的研究进展。作为复苏促进因素(Rpf)的肽聚糖水解酶,是静止状态的放线菌及结核分枝杆菌复苏的关键。从以往发表的数据来看,在结核病小鼠感染模型中,Rpf

目前,结核病仍是威胁人类健康的主要疾病之一,全球有20-30亿人感染结核分支杆菌,形式十分严峻。有效阻断潜伏性结核感染转变为活动性的结核至关重要。

近期,Crit Rev Microbiol杂志中的一篇文章介绍了肽聚糖水解酶在结核分支杆菌及放线菌的复苏的研究进展。

作为复苏促进因素(Rpf)的肽聚糖水解酶,是静止状态的放线菌及结核分枝杆菌复苏的关键。从以往发表的数据来看,在结核病小鼠感染模型中,Rpf是非复制杆菌和病原体的复苏所必须的。尽管其对于人结核分枝杆菌感染的直接影响并不明确。

这篇文章阐述了Rpf在人类结核分枝杆菌发病机制中的作用的认识的进展以及依赖于Rpf的杆菌在结核发展中的重要性。

这篇文章概述了这项研究是如何进行疾病的诊断、治疗及预防的。不断探索与进步,是达到根除结核病的终极目的必要条件。

原始出处:

Rosser A,Stover C,Pareek M,Mukamolova GV.Resuscitation-promoting factors are important determinants of the pathophysiology in Mycobacterium tuberculosis infection.Crit Rev Microbiol. 2017 Feb 17:1-10. doi: 10.1080/1040841X.2017.1283485.

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    2018-03-07 sunylz
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    2017-12-26 xjy02
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