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CELL METAB:临床试验显示,隔日禁食是一种安全的热量限制替代方案

2019-08-31 海北 MedSci原创

已知热量限制和间歇性禁食可以延长模式生物体的生命和健康,但是至今为止,关于它们对人类的影响的研究还较少。

已知热量限制和间歇性禁食可以延长模式生物体的生命和健康,但是至今为止,关于它们对人类的影响的研究还较少。

在最近的一项随机对照试验研究(ClinicalTrials.gov标识符:NCT02673515)中,研究人员发现,为期4周的严格隔日禁食(ADF)改善了健康中年人的一般健康指标,同时平均降低了37%的卡路里。即使在> 6个月后也没有发生不良反应。

ADF改善心血管标志物,减少脂肪量(特别是躯干脂肪),改善脂肪与瘦肉率,并增加β-羟基丁酸盐,即使在非禁食日也是如此。

在禁食日,促老化氨基酸蛋氨酸等定期耗尽,而多不饱和脂肪酸则升高。

研究人员发现,在长期ADF后,sICAM-1(一种与年龄相关的炎症标记物),低密度脂蛋白和代谢调节剂三碘甲状腺原氨酸水平降低。

这些结果揭示了ADF的生理影响并支持其安全性。 ADF最终可能成为临床相关的干预措施。


原始出处:

SlavenStekovic et al. Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese HumansCell Metabolism, 2019; DOI: 10.1016/j.cmet.2019.07.016


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    2019-12-09 维他命
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    2020-07-15 一闲
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    2020-02-18 guojianrong
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