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EASL 2014:肝癌患者生存率与筛查强度相关

2014-04-14 佚名 dxy

肝癌患者的生存率存在地理差异性,其主要原因是内在的民族差异以及不同的病因或疾病阶段。受限于不同国家数据库信息的不同,无法对这些变量的影响进行严格分析。来自英国利物浦大学的进行的一项研究认为,肝癌筛查强度与患者生存率有很大相关性。该研究结果公布于2014年4月9日-4月13日在伦敦举行的EASL2014会上。 研究共纳入了超过5000例患者,分别来自2个高发病区日本(N = 2599,主要是HCV感

肝癌患者的生存率存在地理差异性,其主要原因是内在的民族差异以及不同的病因或疾病阶段。受限于不同国家数据库信息的不同,无法对这些变量的影响进行严格分析。来自英国利物浦大学的进行的一项研究认为,肝癌筛查强度与患者生存率有很大相关性。该研究结果公布于2014年4月9日-4月13日在伦敦举行的EASL2014会上。

研究共纳入了超过5000例患者,分别来自2个高发病区日本(N = 2599,主要是HCV感染)和香港香港(N=1112,主要是HBV感染),2个中等发病区西班牙(N = 834 ,主要是HCV感染和酒精肝)和英国(N = 724 ,多种病因)。研究人员收集了人口、病因、病情和治疗数据等全面信息。

结果显示,日本、西班牙、英国和香港患者的中位生存时间分别为47、26、20和7个月。年龄、性别和Child- Pugh分级分布在所有组中都相似。统计分析表明,病因对生存率影响不大,但疾病的病情存在巨大差异。59%的日本患者符合早期肝癌的米兰标准,71%有治愈可能。西班牙的相对数字分别为26%和32%,英国分别为37%和38%,香港为8%及16%,

研究表明,约80%的日本肝癌病例是通过筛查检测出来的。而英国、西班牙和香港的筛查比例分别为15%、35%和<10%。研究数据表明,诊断时的病情严重程度对筛查方案的强度,以及随之而来的治疗方案产生了巨大影响,与患者生存率具有较强的相关性。

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    2014-04-16 kord1983
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    2014-04-16 lq1771

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