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J Alzheimers Dis:保持口腔卫生可远离痴呆

2013-08-02 刘石磊 新华社

保持口腔卫生不只对牙齿健康有好处。英国一项新研究发现,口腔内一种与牙龈疾病有关的细菌会增加早老性痴呆症(阿尔茨海默病)的风险。 英国中兰开夏大学等机构的研究人员在新一期《阿尔茨海默病杂志》上报告说,他们对比了20名死者的脑组织,这其中有10人患有阿尔茨海默氏症。结果发现,阿尔茨海默氏症患者脑中一种细菌的含量远高于普通人。 这种细菌名为“牙龈卟啉单胞菌”,是引发牙周病的一种主要细菌。此前研究已发

保持口腔卫生不只对牙齿健康有好处。英国一项新研究发现,口腔内一种与牙龈疾病有关的细菌会增加早老性痴呆症(阿尔茨海默病)的风险。

英国中兰开夏大学等机构的研究人员在新一期《阿尔茨海默病杂志》上报告说,他们对比了20名死者的脑组织,这其中有10人患有阿尔茨海默氏症。结果发现,阿尔茨海默氏症患者脑中一种细菌的含量远高于普通人。

这种细菌名为“牙龈卟啉单胞菌”,是引发牙周病的一种主要细菌。此前研究已发现这类致病菌引发的炎症与糖尿病、心脏病和中风风险有关。

研究人员解释说,虽然这种细菌主要生存于口腔内,但它们可能在咀嚼过程中或牙科手术时进入血液循环并进入脑部。之后,它们会在脑部引发过度免疫反应,导致免疫系统释放出化学物质“误杀”脑细胞,造成记忆力丧失、思维混乱等痴呆症症状。

研究人员说,这种影响并不是一夜之间发生的,而是由细菌的不断积累所造成的,因此注意平时口腔卫生、定期检查口腔健康状况对降低这种风险十分重要。

阿尔茨海默氏症是最常见的一种痴呆症,患者脑细胞受损,临床表现为认知、记忆和语言功能出现障碍,目前尚无有效疗法

Poole S, Singhrao SK, Kesavalu L, Curtis MA, Crean SJ.Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue.J Alzheimers Dis. 2013 May 10. [Epub ahead of print]

PMID:
23666172

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    2013-10-27 anminleiryan
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