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Am J Otolaryngol:后鼻神经切除术对过敏性鼻炎的抑制作用研究

2020-03-22 AlexYang MedSci原创

最近的指南阐释了过敏性鼻炎(AR)影响生活质量。神经肽在AR中具有核心的作用。最近,有研究人员确定了后鼻神经切除(PNN)对治疗AR的效果情况以及抑制神经肽和2型细胞因子表达的情况。

最近的指南阐释了过敏性鼻炎(AR)影响生活质量。神经肽在AR中具有核心的作用。最近,有研究人员确定了后鼻神经切除(PNN)对治疗AR的效果情况以及抑制神经肽和2型细胞因子表达的情况。

研究总共包括了77名经历了PNN的患者。研究人员使用一个10cm视觉模拟量表(VAS)的调查问卷评估了主观症状,包括了打喷嚏和流鼻涕;并在随机的17名患者术前和术后1年时收集鼻灌洗液体,使用酶联免疫吸附进行筛选分析。研究发现,术后流鼻涕(6.03±1.31 vs 2.12±1.40, P<0.001)和打喷嚏(5.53±1.25 vs 2.04±1.29, P<0.001)与术前水平相比显著改善;鼻灌洗液中SP和NPY浓度均值分别为91.6±20.9pg/ml和71.5±10.5pg/ml,而术后分别显著下降到了52.9±16.7pg/ml和31.8±8.2pg/ml;骨膜蛋白和IL-5浓度术前分别为215.2±87.7pg/ml, 984.5±181.8pg/ml,术后分别显著减少到了146.1±70.1pg/ml和281.6±74.0pg/ml。

最后,研究人员指出,PNN是安全且具有良好耐受性的,症状(打喷嚏和流鼻涕)评分在术后一年也显著减少。

原始出处:

Wang L, Chen M, Xu M et al. Effect of posterior nasal neurectomy on the suppression of allergic rhinitis. Am J Otolaryngol. 2020.

 

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