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Ann Surg:急诊食管癌及胃癌的预后相关因素

2017-03-26 MedSci MedSci原创

近期,一项发表在杂志Ann Surg上的文章旨在评估与食管癌和胃癌急诊相关的患者自身因素,并进一步评估该队列人群的长期预后。此项研究的研究人群为“医院数据统计”数据库(1997 - 2012年)中接受食管癌或胃癌的患者,根据紧急诊断或选择性诊断进行分类。多因素回归分析用于确定与紧急诊断和预后相关的患者因素。此项研究结果显示:共有35,807例(29.4%)食管癌患者和45,866例(39.6%)胃

近期,一项发表在杂志Ann Surg上的文章旨在评估与食管癌和胃癌急诊相关的患者自身因素,并进一步评估该队列人群的长期预后。


此项研究的研究人群为“医院数据统计”数据库(1997 - 2012年)中接受食管癌或胃癌的患者,根据紧急诊断或选择性诊断进行分类。多因素回归分析用于确定与紧急诊断和预后相关的患者因素。

此项研究结果显示:共有35,807例(29.4%)食管癌患者和45,866例(39.6%)胃癌患者出现紧急情况。年龄≥70岁,女性,非白种人,查尔森合并症指数得分≥3以上以及更多的缺失汤森指数是急诊癌症诊断的独立预测因子。

紧急诊断是所有食管癌患者[风险比(HR)= 1.63,95%置信区间(CI)1.61-1.65]和胃癌患者(HR = 1.20,95%CI 1.16 -1.23)5年死亡率升高的独立预测因素。特别是进行初次急诊诊断并接受手术的患者预后较差(食管癌:HR = 1.35,95%CI 1.27-1.44,胃癌:HR = 1.13 .95%CI 1.04-1.22),并且与选择性诊断患者相比,肝复发显着增加(食管癌:7.1%vs 4.9%; P <0.001,胃癌:7.0%vs 4.8%; P <0.001)。

此项研究表明:由于诊断时转移性疾病的发病率增加,手术后复发率升高,食管癌和胃癌的紧急症状与预后不良相关。

原始出处:
Markar SR, Mackenzie H, et al. Emergency Presentation of Esophagogastric Cancer: Predictors and Long-term Prognosis. Ann Surg. 2017 Mar 20. doi: 10.1097/SLA.0000000000002224. 

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    2017-03-30 laymankey

    感谢分享一下!

    0

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    2017-03-28 zhouqu_8
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    2017-03-26 1e1a50a1m36(暂无匿称)

    食管癌和胃癌的紧急症状与预后不良相关。

    0

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