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Diabetes Care:HbA1c水平和BMI对1型糖尿病的血脂有什么影响?

2016-10-26 MedSci MedSci原创

探讨1型糖尿病患者从青少年时期进入到成年早期,糖化血红蛋白(HbA1c)和体重指数(BMI,测量值为BMI z评分[zBMI])对低密度脂蛋白(LDL)、高密度脂蛋白(HDL)和非HDL轨迹的影响。研究纳入572名青年1型糖尿病患者进行动态额回顾性队列研究,调查血脂值的变化,纵向的中位数时间为9.3年。通过纵向建模,我们描述HbA1c和zBMI与血脂值的关系,并且校正了其他相关因素,包括降脂药物的

探讨1型糖尿病患者从青少年时期进入到成年早期,糖化血红蛋白(HbA1c)和体重指数(BMI,测量值为BMI z评分[zBMI])对低密度脂蛋白(LDL)、高密度脂蛋白(HDL)和非HDL轨迹的影响。

研究纳入572名青年1型糖尿病患者进行动态额回顾性队列研究,调查血脂值的变化,纵向的中位数时间为9.3年。通过纵向建模,我们描述HbA1c和zBMI与血脂值的关系,并且校正了其他相关因素,包括降脂药物的使用。

脂质评估的中位数数量为7(范围2 - 39)。HbA1c每增加1%,LDL水平增加∼2–6 mg/dL,从青春期到青春期后期,LDL水平增加幅度更大。

BMI每增加1 SD,患者10岁时,平均LDL增加2.1 mg/dL,患者19岁时,平均LDL增加8.2 mg/dL。

HbA1c水平和zBMI对非HDL水平的影响,与LDL相似。

HbA1c水平和zBMI对HDL的影响较小,且不依赖于年龄。

结果表明,HbA1c水平和zBMI对LDL和HDL的影响较大,并且与年龄有关。1新糖尿病患者从儿童时期步入成年时期,应评估HbA1c水平和zBMI,以改善血脂情况。

原始出处:

Michelle L. Katz,et al.Influence of HbA1c and BMI on Lipid Trajectories in Youths and Young Adults With Type 1 Diabetes.Diabetes Care 2016 Oct

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    2017-10-01 Smile2680
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