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NEJM:系统性硬化症钙化病-病例报道

2019-10-24 xing.T MedSci原创

尽管尝试了多种药物治疗,但患者的手指仍出现进行性疼痛和麻木感,处理部位的难度不断增加,因此被转诊进行手术评估,以切除病变部位。

患者为一名77岁右利手女性,患有皮肤局限性系统性硬化,因指尖缓慢进行性、疼痛性肿胀2年而到风湿科就诊。

体格检查时,患者的脸部和胸部有毛细血管扩张,右手、前臂和脸部都有皮肤增厚,以及双手手指尖的软组织肿胀(如图A和图B所示)。毛细血管镜检查发现毛细血管紊乱,无血管区域和毛细血管扩大。



手部X光片显示右手的第一、第二和第三指的远端指骨和左手的第一指的远端钙化(如图C所示),与钙化病一致,这是皮肤局限性系统性硬化的一种表现。这些钙沉积物可能增大,溃疡并被感染

尽管尝试了多种药物治疗,但患者的手指仍出现进行性疼痛和麻木感,处理部位的难度不断增加,因此被转诊进行手术评估,以切除病变部位。 
 
原始出处:

Ana Valido,et al.Calcinosis in Systemic Sclerosis.N Engl J Med 2019;https://www.nejm.org/doi/full/10.1056/NEJMicm1901830

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    2020-03-23 lg.zhao
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    2019-10-24 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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