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BMJ:2型糖尿患者收缩压低于推荐水平,效果可能会更好

2016-08-05 fsy 译 MedSci原创

该研究旨在对那些符合目前的建议收缩压(即,低于140 mm Hg)人群的相关的风险与那些具有较低水平收缩压的2型糖尿病患者(以前没有心血管疾病)的风险进行比较。原始出处:Samuel Adamsson Eryd, Soffia Gudbjörnsdottir,Karin Manhem, et al.Blood pressure and complications in individuals wi

该研究旨在对那些符合目前的建议收缩压(即,低于140 mmHg)2型糖尿病人群的相关的风险与那些具有较低水平收缩压的2型糖尿病患者(以前没有心血管疾病)的风险进行比较。

来自瑞典的研究人员进行了一项以人群为基础的队列研究,采用了2006-12年临床全国登记数据。平均随访时间为5.0年。该研究在瑞典的861个初级保健单位和医院的门诊部进行。

共有187106例患者在瑞典国家糖尿病登记处进行注册,这些患者曾经患2型糖尿病至少一年,年龄在75岁或以下,并且没有心血管疾病或其他重大疾病史。

研究人员从出院和死亡登记处获得了临床事件的信息,这些临床事件包括急性心肌梗塞、卒中、急性心肌梗塞和卒中的复合事件(心血管病)、冠状动脉心脏疾病、心脏衰竭和总死亡率。研究人员估计了不同水平的基线收缩压与临床特征的危险比率,将药物处方数据作为协变量。

具有最低收缩压(110-119 mmHg)的患者与对照组(130-139 mmHg)相比,非致命性急性心肌梗死(校正风险比0.76,95%置信区间 0.64至0.91; P=0.003)、总急性心肌梗塞(0.85,0.72至0.99; P=0.04)、非致死性心血管疾病(0.82,0.72至0.93; P=0.002)、总心血管疾病(0.88,0.79至0.99; P=0.04)和非致命性冠状动脉心脏病(0.88,0.78至0.99; P=0.03)的风险显著降低。除了心衰和总死亡率,没有迹象表明收缩压和终点之间呈J形关系。

在2型糖尿病患者中,如果其收缩压低于目前推荐的收缩压水平,则心血管事件风险显著降低。低血压和死亡率增加之间的关联可能是由于伴随疾病引起的,而不是抗高血压治疗引起的。

原始出处:

Samuel Adamsson Eryd, Soffia Gudbjörnsdottir,Karin Manhem, et al.Blood pressure and complications in individuals with type 2 diabetes and no previous cardiovascular disease,BMJ,2016.8.4

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    2017-01-02 gaoxiaoe
  3. [GetPortalCommentsPageByObjectIdResponse(id=1840295, encodeId=98cb18402954a, content=<a href='/topic/show?id=10905e20546' target=_blank style='color:#2F92EE;'>#收缩压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57205, encryptionId=10905e20546, topicName=收缩压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Wed Oct 12 16:47:00 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848055, encodeId=406d1848055a2, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon Jan 02 13:47:00 CST 2017, time=2017-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141600, encodeId=cf2f14160022, content=谢谢谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sat Oct 08 00:00:47 CST 2016, time=2016-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131746, encodeId=538e131e46e8, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 20 22:25:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125490, encodeId=8ee912549033, content=控制好血压对糖尿病患者也很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 16:17:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-10-08 1e0ece0dm09(暂无匿称)

    谢谢谢谢分享

    0

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    2016-09-20 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

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    2016-09-13 舒心和人

    控制好血压对糖尿病患者也很重要

    0

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