Chemistry ＆biology：局部荧光探针可以检测肠癌啦！

2015-01-28 佚名生物谷

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近日，国际化学与生物学杂志chemistry＆biology发表了来自斯坦福大学医学院Matthew Bogyo研究小组的一项最新研究成果，他们发现一种荧光淬灭探针（aABP）能够特异性靶向在肠道发育不良中高表达的半胱氨酸蛋白酶，对指示肠道肿瘤具有非常高的敏感性和特异性。

早期检测结肠息肉能够预防高达90%的结肠癌病人死亡，传统的结肠镜检查能够便捷检测大多数的已表现出特定形态的癌前病变，但对于潜伏病变，结肠镜检查并不能有效检测。因此基于分子差别开发检测试剂提高肠癌的检测率变得十分必要。

之前研究发现半胱氨酸蛋白酶在自发性肠息肉和化学诱导结肠癌导致的肠道不良发育中具有非常高的表达水平。本文研究人员针对检测半胱氨酸蛋白酶发现了一种荧光淬灭探针（aABP），能够选择性靶向多种半胱氨酸蛋白酶，并且发现aABP通过靶向半胱氨酸蛋白酶，提高了对人和小鼠肠道肿瘤识别的敏感性和特异性。除此之外，aABP能够通过静脉注射给药或结肠部局部给药,减少病人检测时的痛苦。

综上所述，该文章发现了一种特异性识别半胱氨酸蛋白酶的荧光探针，并提出应用荧光引导下结肠镜检查技术能够有效提高对肠道肿瘤的检测，预防结肠癌。这一发现或许对临床检测肠道肿瘤具有非常重要的意义。

原始出处

Segal E1, Prestwood TR1, van der Linden WA1, Carmi Y1, Bhattacharya N1, Withana N1, Verdoes M1, Habtezion A2, Engleman EG1, Bogyo M3.Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins.Chem Biol. 2015 Jan 22

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2015-11-02 kzlchina

#chemistry#

105 0
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2015-11-23 sunylz

#Bio#

58 0
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2015-10-14 doctor-chen9582

#荧光探针#

55 0
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2015-04-16 lvygwyt2793

#探针#

51 0
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2016-01-01 ms6897892027066920

#荧光#

62 0
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2015-02-23 orthoW

不错的文章，学习了

174 0
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2016-01-09 12498ebem31暂无昵称

#Biol#

47 0
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2015-01-30 chg122

#局部#

55 0

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