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2019逆转录病毒和机会性感染会议CROI报道:感染HCV后接受直接抗病毒药物治疗的患者患糖尿病的风险降低

2019-03-10 不详 MedSci原创

2019年逆转录病毒和机会性感染会议(CROI)上发布,回顾性研究结果显示,感染丙型肝炎病毒HCV后治疗过的患者患糖尿病的风险降低,特别是通过直接抗病毒方案清除感染的患者患病率更低。

2019年逆转录病毒和机会性感染会议(CROI)上发布,回顾性研究结果显示,感染丙型肝炎病毒HCV后治疗过的患者患糖尿病的风险降低,特别是通过直接抗病毒方案清除感染的患者患病率更低。

宾夕法尼亚州匹兹堡大学医学院的医学博士Adeel Butt表示,糖尿病发病很大程度由抗病毒药物干扰素/利巴韦林所影响。尤其是在晚期肝纤维化或肝硬化患者中,治疗的益处更为明显。

Butt博士及其同事研究了退伍军人事务数据库,发现HCV感染后未治疗的患者中有1679例糖尿病(发病率为20.6 / 1000患者每年),而HCV感染后接受治疗的患新发病例仅为888例(发病率为15.4 / 1000患者每年),P <.001。

其中,在接受直接作用的抗病毒药物的患者中,仅发现255例新发糖尿病,但发病率为9.89 / 1000患者每年(P <.001)。

Butt博士总结道:"使用直接作用抗病毒治疗方案治疗HCV感染可带来超出病毒学控制的益处,并可能有助于控制或减轻丙型肝炎病毒的一些肝外并发症。"

原始出处:


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    2019-05-05 hxj0117
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    2019-09-17 mjldent
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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489488, encodeId=3e7e148948835, content=<a href='/topic/show?id=6f71e24390c' target=_blank style='color:#2F92EE;'>#直接抗病毒药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72439, encryptionId=6f71e24390c, topicName=直接抗病毒药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fe638558169, createdName=crystal0565, createdTime=Tue Mar 12 06:52:00 CST 2019, time=2019-03-12, status=1, ipAttribution=)]
    2019-03-12 ymljack
  8. 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    2019-03-12 yahu
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一项新的研究表明,直接作用的抗病毒治疗在慢性肾脏疾病(CKD)和丙型肝炎病毒(HCV)感染患者中是安全有效的。美国肾脏病学杂志(CJASN)即将出版的研究报告也发现,治疗可能有助于改善一些患者的肾功能。

CCLM:比较两种丙型肝炎病毒基因分型的方法

丙型肝炎病毒(HCV)基因型可以作为治疗的预测指标。研究人员依次评估了两种核酸扩增试验(NAATs)和一种HCV基因型的血清学检测方法,包括Abbott RealTi me基因型II(RealTi me II),GeneMatrix限制性片段质量多态性(RFM)和Sysmex HISCL HCV Gr(HISCL Gr )。研究人员用三个检测方法检查了281个临床样本,使用HCV基因型性能亚组PH

2018美国肝脏会议:丙型肝炎病毒感染的器官被认为对移植安全

导语 一项新的研究显示,直接作用的抗病毒药物可以使感染丙型肝炎的器官移植到没有病毒的受者身上。

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