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J Periodontal Res:单纯疱疹病毒1型(HSV-1)的存在与牙龈炎和牙周炎的发生有关吗?

2022-04-08 MedSci原创 MedSci原创

单纯疱疹病毒1型(HSV-1)可能是口面部最常见的病原体,全世界有35亿人受到感染。 本项研究探究了HSV-1与牙周炎之间的关联。

单纯疱疹病毒1型(HSV-1)可能是口面部最常见的病原体,全世界有35亿人受到感染。近日,发表于J Periodontal Res的一项观察性研究的荟萃分析旨在探究单纯疱疹病毒1型(HSV-1)在菌斑诱发的牙龈炎和牙周炎受试者中的关联强度和普遍性。

 

研究人员通过PubMed、Scopus、Web of Science和Google Scholar的MEDLINE搜索病例对照和横断面研究,调查龈下菌斑/龈沟液和牙周状况中的HSV-1水平。从每项研究中提取OR和95% CI,并对牙周炎、慢性和侵袭性牙龈炎的汇总OR进行了评估。荟萃分析方法是根据异质性的程度来选择的。通过二级分析,包括对研究质量、出版偏差和研究纳入的敏感性分析,以及对发表主要研究的科学期刊质量、世界区域、龈下斑块采样方法和研究设计的亚组分析,研究了由荟萃分析偏差决定的结果的普适性。

 

结果,这项荟萃分析共纳入12项研究(738名病例,551名对照者)。所有牙周炎的汇总ORs为4.4(95CI,1.9-10.2);具体而言,慢性牙周炎为2.8(95CI,1.0-8.3),侵袭性牙周炎为11.8(95CI,5.4-25.8),牙龈炎为4.8(95CI,2.1-11.0)。除了慢性牙周炎(P = 0.05)外,其他结果均有统计学差异。

综上所述,该研究结果表明,龈下菌斑/龈沟液中的HSV-1与牙周炎的发病急强度有关,但是与牙龈炎有关的数据并未确定。探究龈下菌斑中HSV-1的水平有助于评估牙周炎的发病风险和严重程度,若证实有因果关系,则有助于控制牙周炎。

 

原始出处:

 

Paolo G Arduino,et al., Herpes simplex virus type 1 in subgingival plaque and periodontal diseases. Meta-analysis of observational studies. J Periodontal Res. 2022 Apr;57(2):256-268. doi: 10.1111/jre.12968.

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    2022-12-27 ms6000001411380643 来自广东省

    希望国家重视!单纯疱疹要害死人,加快根治药物研究

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    2022-12-27 ms6000001411380643 来自广东省

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    0

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    2022-07-08 gracezdd
  4. 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href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Fri Jul 08 03:09:00 CST 2022, time=2022-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729480, encodeId=ef241e2948041, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Oct 04 10:09:00 CST 2022, time=2022-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987773, encodeId=72e7198e7734e, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=217, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Mon Oct 10 12:09:00 CST 2022, time=2022-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351518, encodeId=0f02135151852, content=<a href='/topic/show?id=d1c76e735bf' target=_blank style='color:#2F92EE;'>#牙龈炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67735, encryptionId=d1c76e735bf, topicName=牙龈炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451377, encodeId=6c1114513e714, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490584, encodeId=f21a1490584b3, content=<a href='/topic/show?id=7b98362e8f8' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36278, encryptionId=7b98362e8f8, topicName=单纯疱疹病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a61f8789613, createdName=cnxcy, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580494, encodeId=0022158049486, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1209528, encodeId=05611209528e7, content=好文章,值得一读。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Fri Apr 08 12:00:29 CST 2022, time=2022-04-08, status=1, ipAttribution=)]
    2022-10-04 feather89
  5. [GetPortalCommentsPageByObjectIdResponse(id=2107658, encodeId=daa8210e658db, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=284, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:44:14 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=2107654, encodeId=ca1a210e654eb, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=433, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:39:10 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1941653, encodeId=f39219416535c, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Fri Jul 08 03:09:00 CST 2022, time=2022-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729480, encodeId=ef241e2948041, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Oct 04 10:09:00 CST 2022, time=2022-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987773, encodeId=72e7198e7734e, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=217, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Mon Oct 10 12:09:00 CST 2022, time=2022-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351518, encodeId=0f02135151852, content=<a href='/topic/show?id=d1c76e735bf' target=_blank style='color:#2F92EE;'>#牙龈炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67735, encryptionId=d1c76e735bf, topicName=牙龈炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451377, encodeId=6c1114513e714, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490584, encodeId=f21a1490584b3, content=<a href='/topic/show?id=7b98362e8f8' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36278, encryptionId=7b98362e8f8, topicName=单纯疱疹病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a61f8789613, createdName=cnxcy, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580494, encodeId=0022158049486, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1209528, encodeId=05611209528e7, content=好文章,值得一读。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Fri Apr 08 12:00:29 CST 2022, time=2022-04-08, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2107658, encodeId=daa8210e658db, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=284, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:44:14 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=2107654, encodeId=ca1a210e654eb, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=433, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:39:10 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1941653, encodeId=f39219416535c, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Fri Jul 08 03:09:00 CST 2022, time=2022-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729480, encodeId=ef241e2948041, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Oct 04 10:09:00 CST 2022, time=2022-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987773, encodeId=72e7198e7734e, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=217, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Mon Oct 10 12:09:00 CST 2022, time=2022-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351518, encodeId=0f02135151852, content=<a href='/topic/show?id=d1c76e735bf' target=_blank style='color:#2F92EE;'>#牙龈炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67735, encryptionId=d1c76e735bf, topicName=牙龈炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451377, encodeId=6c1114513e714, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490584, encodeId=f21a1490584b3, content=<a href='/topic/show?id=7b98362e8f8' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36278, encryptionId=7b98362e8f8, topicName=单纯疱疹病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a61f8789613, createdName=cnxcy, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580494, encodeId=0022158049486, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1209528, encodeId=05611209528e7, content=好文章,值得一读。, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Fri Apr 08 12:00:29 CST 2022, time=2022-04-08, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2107658, encodeId=daa8210e658db, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=284, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:44:14 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=2107654, encodeId=ca1a210e654eb, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=433, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:39:10 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1941653, encodeId=f39219416535c, content=<a 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987773, encodeId=72e7198e7734e, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=217, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Mon Oct 10 12:09:00 CST 2022, time=2022-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351518, encodeId=0f02135151852, content=<a href='/topic/show?id=d1c76e735bf' target=_blank style='color:#2F92EE;'>#牙龈炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67735, encryptionId=d1c76e735bf, topicName=牙龈炎)], attachment=null, authenticateStatus=null, createdAvatar=, 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  8. 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  9. 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  10. 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createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451377, encodeId=6c1114513e714, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sat Apr 09 08:09:00 CST 2022, time=2022-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490584, encodeId=f21a1490584b3, content=<a href='/topic/show?id=7b98362e8f8' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36278, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Fri Apr 08 12:00:29 CST 2022, time=2022-04-08, status=1, ipAttribution=)]
    2022-04-08 yangchou

    好文章,值得一读。

    0

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