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每天只需6分钟运动,促进大脑重要蛋白形成,预防痴呆

2023-01-19 医诺维 医诺维 发表于安徽省

我们现在正在研究长时间禁食(最多三天)如何影响BDNF,我们很好奇在禁食开始时进行剧烈运动是否会加速禁食的有益效果,我们认为禁食和运动可以结合使用来优化人脑中BDNF的产生。

生命的意义在于运动,运动和健康是正相关的关系。运动,是改善和维持我们身体健康最重要的行为之一。越来越多的研究显示,运动具有诸多益处,有助于预防心脑血管疾病、糖尿病、肥胖,改善情绪,甚至能改善多种癌症治疗效果。

脑源性神经营养因子(BDNF),是一种特殊蛋白质,有助于学习和记忆,可促进神经可塑性和神经元的存活,并且可能是其中一些神经保护作用的基础。

2023年1月11日,新西兰奥塔哥大学的研究人员在" The Journal of Physiology "期刊上发表了一篇题为" Fasting for 20 h does not affect exercise-induced increases in circulating BDNF in humans "的研究论文。

该研究表明,每天只需六分钟的剧烈运动,就可以预防痴呆症。短时间高强度运动会增加脑源性神经营养因子的产生,对大脑形成、学习和记忆至关重要,并且可以保护大脑免受与年龄相关的认知衰退影响。

早期动物研究表明,增加BDNF的可用性会促进记忆的形成和储存,增强学习能力,并全面提高认知能力。

BDNF在动物模型中表现出了巨大的潜力,但药物干预迄今未能安全地利用BDNF对人类的保护作用。所以,研究人员探索了非药理学方法,以保护大脑的能力,人类可以利用这些方法自然增加BDNF,以帮助健康衰老。

在该研究中,研究人员招募了12名参与者,男女各半,年龄在18-56岁之间,比较了禁食20小时、轻度运动(90分钟轻度骑行)、高强度运动(6分钟剧烈骑)、禁食结合运动对BDNF产生的影响。

研究发现,短时间高强度运动是增加BDNF的最有效方法。

具体来说,与之相比,禁食不影响BDNF浓度;长时间轻度运动BDNF浓度略有增加,从336增加至390;而短时间高强度运动让BDNF浓度增加了4-5倍,从396增加至1170。

对于轻度运动,这种现象可能是由于储存大量BDNF的血小板数量增加所致,并且需要增加运动持续时间或运动强度来释放游离的、生物可利用的BDNF。与禁食相比,血液中循环的血小板浓度受运动的影响更大,上升了20%。

研究人员猜测,在运动期间,大脑能量来源从代谢葡萄糖转变为乳酸,以确保满足身体的能量需求,从消耗糖到乳酸的转变,导致血液中BDNF水平升高。

研究人员表示,这些差异的原因尚不清楚,需要更多的研究来理解其中的机制。

总之,研究显示,短时间高强度运动是增加BDNF的最有效方法,对大脑形成、学习和记忆至关重要,并且可以保护大脑免受与年龄相关的认知衰退的影响。

目前,研究人员正在进行研究,以更深入地研究卡路里限制和锻炼的影响,以区分对BDNF的影响和认知益处。

研究人员指出,我们现在正在研究长时间禁食(最多三天)如何影响BDNF,我们很好奇在禁食开始时进行剧烈运动是否会加速禁食的有益效果,我们认为禁食和运动可以结合使用来优化人脑中BDNF的产生。

论文链接:

https://doi.org/10.1113/JP283582

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2110944, encodeId=a25021109440f, content=脑源性神经营养因子(BDNF),是一种特殊蛋白质,有助于学习和记忆,可促进神经可塑性和神经元的存活,并且可能是其中一些神经保护作用的基础。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210925/20274508595745adb221d4af84f71a30/44cac845ab1e4a3a81ff3fe6373b97b0.jpg, createdBy=2a601767050, createdName=Mongolian, createdTime=Fri Jan 20 07:12:05 CST 2023, time=2023-01-20, status=1, ipAttribution=内蒙古), GetPortalCommentsPageByObjectIdResponse(id=2110940, encodeId=c6ee2110940b5, content=运动起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3d3015017, createdName=jshbyywk2008, createdTime=Fri Jan 20 06:47:04 CST 2023, time=2023-01-20, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2110900, encodeId=4e42211090063, content=每天只需六分钟的剧烈运动,就可以预防痴呆症。短时间高强度运动会增加脑源性神经营养因子的产生,对大脑形成、学习和记忆至关重要,并且可以保护大脑免受与年龄相关的认知衰退影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6fee1369959, createdName=1649020726, createdTime=Thu Jan 19 21:41:22 CST 2023, time=2023-01-19, status=1, ipAttribution=陕西省), GetPortalCommentsPageByObjectIdResponse(id=2110899, encodeId=13b3211089934, content=预防痴呆, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6fee1369959, createdName=1649020726, createdTime=Thu Jan 19 21:40:42 CST 2023, time=2023-01-19, status=1, ipAttribution=陕西省), GetPortalCommentsPageByObjectIdResponse(id=2110896, encodeId=cb6b21108969d, content=脑源性神经营养因子, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65724176436, createdName=13d0179fm99暂无昵称, createdTime=Thu Jan 19 21:32:16 CST 2023, time=2023-01-19, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2110962, encodeId=cc86211096210, content=|x奶好/人白的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Fri Jan 20 10:04:34 CST 2023, time=2023-01-20, status=1, ipAttribution=山东省)]
    2023-01-20 Mongolian 来自内蒙古

    脑源性神经营养因子(BDNF),是一种特殊蛋白质,有助于学习和记忆,可促进神经可塑性和神经元的存活,并且可能是其中一些神经保护作用的基础。

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2110944, encodeId=a25021109440f, content=脑源性神经营养因子(BDNF),是一种特殊蛋白质,有助于学习和记忆,可促进神经可塑性和神经元的存活,并且可能是其中一些神经保护作用的基础。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210925/20274508595745adb221d4af84f71a30/44cac845ab1e4a3a81ff3fe6373b97b0.jpg, createdBy=2a601767050, createdName=Mongolian, createdTime=Fri Jan 20 07:12:05 CST 2023, time=2023-01-20, status=1, ipAttribution=内蒙古), GetPortalCommentsPageByObjectIdResponse(id=2110940, encodeId=c6ee2110940b5, content=运动起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3d3015017, createdName=jshbyywk2008, createdTime=Fri Jan 20 06:47:04 CST 2023, time=2023-01-20, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2110900, encodeId=4e42211090063, content=每天只需六分钟的剧烈运动,就可以预防痴呆症。短时间高强度运动会增加脑源性神经营养因子的产生,对大脑形成、学习和记忆至关重要,并且可以保护大脑免受与年龄相关的认知衰退影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6fee1369959, createdName=1649020726, createdTime=Thu Jan 19 21:41:22 CST 2023, time=2023-01-19, status=1, ipAttribution=陕西省), GetPortalCommentsPageByObjectIdResponse(id=2110899, encodeId=13b3211089934, content=预防痴呆, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6fee1369959, createdName=1649020726, createdTime=Thu Jan 19 21:40:42 CST 2023, time=2023-01-19, status=1, ipAttribution=陕西省), GetPortalCommentsPageByObjectIdResponse(id=2110896, encodeId=cb6b21108969d, content=脑源性神经营养因子, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65724176436, createdName=13d0179fm99暂无昵称, createdTime=Thu Jan 19 21:32:16 CST 2023, time=2023-01-19, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2110962, encodeId=cc86211096210, content=|x奶好/人白的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Fri Jan 20 10:04:34 CST 2023, time=2023-01-20, status=1, ipAttribution=山东省)]
    2023-01-20 jshbyywk2008 来自河北省

    运动起来

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2110944, encodeId=a25021109440f, content=脑源性神经营养因子(BDNF),是一种特殊蛋白质,有助于学习和记忆,可促进神经可塑性和神经元的存活,并且可能是其中一些神经保护作用的基础。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210925/20274508595745adb221d4af84f71a30/44cac845ab1e4a3a81ff3fe6373b97b0.jpg, createdBy=2a601767050, createdName=Mongolian, createdTime=Fri Jan 20 07:12:05 CST 2023, time=2023-01-20, status=1, ipAttribution=内蒙古), GetPortalCommentsPageByObjectIdResponse(id=2110940, encodeId=c6ee2110940b5, content=运动起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3d3015017, createdName=jshbyywk2008, createdTime=Fri Jan 20 06:47:04 CST 2023, time=2023-01-20, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2110900, encodeId=4e42211090063, content=每天只需六分钟的剧烈运动,就可以预防痴呆症。短时间高强度运动会增加脑源性神经营养因子的产生,对大脑形成、学习和记忆至关重要,并且可以保护大脑免受与年龄相关的认知衰退影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6fee1369959, createdName=1649020726, createdTime=Thu Jan 19 21:41:22 CST 2023, time=2023-01-19, status=1, ipAttribution=陕西省), GetPortalCommentsPageByObjectIdResponse(id=2110899, encodeId=13b3211089934, content=预防痴呆, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6fee1369959, createdName=1649020726, createdTime=Thu Jan 19 21:40:42 CST 2023, time=2023-01-19, status=1, ipAttribution=陕西省), GetPortalCommentsPageByObjectIdResponse(id=2110896, encodeId=cb6b21108969d, content=脑源性神经营养因子, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65724176436, createdName=13d0179fm99暂无昵称, createdTime=Thu Jan 19 21:32:16 CST 2023, time=2023-01-19, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2110962, encodeId=cc86211096210, content=|x奶好/人白的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Fri Jan 20 10:04:34 CST 2023, time=2023-01-20, status=1, ipAttribution=山东省)]
    2023-01-19 1649020726 来自陕西省

    每天只需六分钟的剧烈运动,就可以预防痴呆症。短时间高强度运动会增加脑源性神经营养因子的产生,对大脑形成、学习和记忆至关重要,并且可以保护大脑免受与年龄相关的认知衰退影响。

    0

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    2023-01-19 1649020726 来自陕西省

    预防痴呆

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2110944, encodeId=a25021109440f, content=脑源性神经营养因子(BDNF),是一种特殊蛋白质,有助于学习和记忆,可促进神经可塑性和神经元的存活,并且可能是其中一些神经保护作用的基础。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210925/20274508595745adb221d4af84f71a30/44cac845ab1e4a3a81ff3fe6373b97b0.jpg, createdBy=2a601767050, createdName=Mongolian, createdTime=Fri Jan 20 07:12:05 CST 2023, time=2023-01-20, status=1, ipAttribution=内蒙古), GetPortalCommentsPageByObjectIdResponse(id=2110940, encodeId=c6ee2110940b5, content=运动起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3d3015017, createdName=jshbyywk2008, createdTime=Fri Jan 20 06:47:04 CST 2023, time=2023-01-20, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2110900, encodeId=4e42211090063, content=每天只需六分钟的剧烈运动,就可以预防痴呆症。短时间高强度运动会增加脑源性神经营养因子的产生,对大脑形成、学习和记忆至关重要,并且可以保护大脑免受与年龄相关的认知衰退影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6fee1369959, createdName=1649020726, createdTime=Thu Jan 19 21:41:22 CST 2023, time=2023-01-19, status=1, ipAttribution=陕西省), GetPortalCommentsPageByObjectIdResponse(id=2110899, encodeId=13b3211089934, content=预防痴呆, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6fee1369959, createdName=1649020726, createdTime=Thu Jan 19 21:40:42 CST 2023, time=2023-01-19, status=1, ipAttribution=陕西省), GetPortalCommentsPageByObjectIdResponse(id=2110896, encodeId=cb6b21108969d, content=脑源性神经营养因子, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65724176436, createdName=13d0179fm99暂无昵称, createdTime=Thu Jan 19 21:32:16 CST 2023, time=2023-01-19, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2110962, encodeId=cc86211096210, content=|x奶好/人白的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Fri Jan 20 10:04:34 CST 2023, time=2023-01-20, status=1, ipAttribution=山东省)]
    2023-01-19 13d0179fm99暂无昵称 来自山西省

    脑源性神经营养因子

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2110944, encodeId=a25021109440f, content=脑源性神经营养因子(BDNF),是一种特殊蛋白质,有助于学习和记忆,可促进神经可塑性和神经元的存活,并且可能是其中一些神经保护作用的基础。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210925/20274508595745adb221d4af84f71a30/44cac845ab1e4a3a81ff3fe6373b97b0.jpg, createdBy=2a601767050, createdName=Mongolian, createdTime=Fri Jan 20 07:12:05 CST 2023, time=2023-01-20, status=1, ipAttribution=内蒙古), GetPortalCommentsPageByObjectIdResponse(id=2110940, encodeId=c6ee2110940b5, content=运动起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3d3015017, createdName=jshbyywk2008, createdTime=Fri Jan 20 06:47:04 CST 2023, time=2023-01-20, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2110900, encodeId=4e42211090063, content=每天只需六分钟的剧烈运动,就可以预防痴呆症。短时间高强度运动会增加脑源性神经营养因子的产生,对大脑形成、学习和记忆至关重要,并且可以保护大脑免受与年龄相关的认知衰退影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6fee1369959, createdName=1649020726, createdTime=Thu Jan 19 21:41:22 CST 2023, time=2023-01-19, status=1, ipAttribution=陕西省), GetPortalCommentsPageByObjectIdResponse(id=2110899, encodeId=13b3211089934, content=预防痴呆, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6fee1369959, createdName=1649020726, createdTime=Thu Jan 19 21:40:42 CST 2023, time=2023-01-19, status=1, ipAttribution=陕西省), GetPortalCommentsPageByObjectIdResponse(id=2110896, encodeId=cb6b21108969d, content=脑源性神经营养因子, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65724176436, createdName=13d0179fm99暂无昵称, createdTime=Thu Jan 19 21:32:16 CST 2023, time=2023-01-19, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2110962, encodeId=cc86211096210, content=|x奶好/人白的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Fri Jan 20 10:04:34 CST 2023, time=2023-01-20, status=1, ipAttribution=山东省)]
    2023-01-20 八骏奔腾 来自山东省

    |x奶好/人白的

    0

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