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Pediatrics:小儿烧伤后很长一段时间循环系统都更脆弱

2015-10-20 Mechront 译 MedSci原创

已有研究表明,机体对烧伤产生的系统性反应(尤其是体内儿茶酚胺、应激相关激素浓度的增加)会对患者循环系统功能造成持久的影响,起码也是3年以上的影响。不过烧伤是否会造成患儿因循环系统疾病而住院的发生率增加尚不明确。研究者进行了一项基于人群的纵向研究,该研究纳入了1980-2012年间≤15岁因初次烧伤住院的患儿(n = 10 436),随机匹配非烧伤的对照组 (n = 40 819)。统计两组人群烧伤

已有研究表明,机体对烧伤产生的系统性反应(尤其是体内儿茶酚胺、应激相关激素浓度的增加)会对患者循环系统功能造成持久的影响,起码也是3年以上的影响。不过烧伤是否会造成患儿因循环系统疾病而住院的发生率增加尚不明确。

研究者进行了一项基于人群的纵向研究,该研究纳入了1980-2012年间≤15岁因初次烧伤住院的患儿(n = 10 436),随机匹配非烧伤的对照组 (n = 40 819)。统计两组人群烧伤后因循环系统疾病而住院的发生率以及住院时长。研究者根据负二项和Cox风险比例模型比较两组的患病情况以及风险。

通过校正地理因素、既往健康情况等混杂因素后,研究者发现烧伤队列因循环系统疾病住院的发生率是对照组的1.33倍 (95% CI: 1.08-1.64);烧伤组诊断为循环系统疾病的天数是对照组的2.26倍(2.26, 95% CI: 1.06-4.81);并且烧伤组通常因循环系统疾病住院的风险更高 (HR 1.22, 95% CI: 1.03-1.46)。

该研究表明,对于有烧伤经历的小儿,其未来的很长一段时间,因为循环系统疾病而住院的风险会增加,住院时间也会增加。

原始出处:

Duke JM, Randall SM, Fear MW,et al.Long-term Effects of Pediatric Burns on the Circulatory System.Pediatrics. 2015 Oct 12. pii: peds.2015-1945.
 

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    2015-11-16 hbwxf
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    2015-12-11 feather89
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    2015-10-26 slicer

    应急型溃疡

    0

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    2015-10-22 三三五五

    0

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