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科学家发现结核杆菌抗癌新方法

2011-04-04 MedSci原创 MedSci原创

MedSci:实际上,很多年前就已发现使用卡介苗可以用于多种肿瘤,如卡介苗灌注可以用于膀胱癌的治疗。但是具体机制并不清楚,以往仅认为可能与免疫激活有关,实际上还有可能有其它更深入的机制。这篇文章在此基础上进行进一步研究。这种反向思维方式,往往便于产生新的发现。   韩国研究人员3月21日说,他们发现了一种利用结核杆菌抗癌的新方法。成果发表在最新一期《癌症研究》(Cancer Resea

MedSci:实际上,很多年前就已发现使用卡介苗可以用于多种肿瘤,如卡介苗灌注可以用于膀胱癌的治疗。但是具体机制并不清楚,以往仅认为可能与免疫激活有关,实际上还有可能有其它更深入的机制。这篇文章在此基础上进行进一步研究。这种反向思维方式,往往便于产生新的发现。

  韩国研究人员3月21日说,他们发现了一种利用结核杆菌抗癌的新方法。成果发表在最新一期《癌症研究》(Cancer Research)杂志上。

  结核杆菌是导致肺结核病的“罪魁祸首”。但研究人员从结核杆菌中成功提取肝素结合血凝素蛋白,再借助激活树突细胞的方法,研制出一种有效的治疗性癌症疫苗。

  这项研究由韩国釜山大学医学教授朴永明(音译)引领,朴永明说,实验鼠接种疫苗后,体内肿瘤明显减小。

  “研究人员知道结核杆菌突变可用于抗癌或治疗糖尿病已有一段时间,”朴永明说,“但严重的副作用让人们无法利用(结核杆菌治疗疾病)。”

  不过他说,研究人员发现的这种抗癌新法能够“克服这些缺点”。而且,研究人员利用患癌动物体内的树突细胞“培育”肝素结合血凝素蛋白,可避免患病动物机体产生排异反应,有助治疗。

  朴永明说,除可减小肿瘤外,新疫苗还可在患癌动物体内“触发”积极免疫反应,防止癌症恶化。

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