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J Hepatol:男男性接触的HIV患者中HCV的再感染率很高

2016-10-31 MedSci MedSci原创

在过去的十年中,男男性接触的HIV患者中,使用聚乙二醇干扰素和利巴韦林联合治疗急性丙型肝炎病毒感染的治愈率可达中等。然而,在已经清除病毒和对治疗有反应的男性中随后的HCV再感染发生率较高。采用回顾性分析探究来自奥地利、法国、德国和英国八个中心的男性HIV患者HCV的再感染率,时间为2002年5月至2014年6月。结果,606名自发清除HCV或治疗成功的患者中,149名(24.6%)患者出现了后续H

在过去的十年中,男男性接触的HIV患者中,使用聚乙二醇干扰素和利巴韦林联合治疗急性丙型肝炎病毒感染的治愈率可达中等。然而,在已经清除病毒和对治疗有反应的男性中随后的HCV再感染发生率较高。

采用回顾性分析探究来自奥地利、法国、德国和英国八个中心的男性HIV患者HCV的再感染率,时间为2002年5月至2014年6月。

结果,606名自发清除HCV或治疗成功的患者中,149名(24.6%)患者出现了后续HCV再感染。30名(共70名,43%)再次清除或治疗成功的患者发烧二次感染。再感染发生率为7.3/100人年(95% CI 6.2-8.6)。自发清除感染的患者较比接受治疗的患者再感染的发生率较低(危害比0.62,95% CI 0.38-1.02,P = 0.06)。再感染的自然清除与ALT的水平> 1000 IU/mL和先前感染的自然清除相关。

男男性接触的HIV患者中HCV感染是一个需要主要关心的问题。在此高风险群体种需要制定预防措施以减少发病率和治疗成本。存在HCV感染史的患者每3-6个月应检测其再感染情况,再感染者应每3个月检测一次。

原始出处:

Patrick Ingiliz, et al., HCV reinfection incidence and spontaneous clearance rates in HIV-positive men who have sex with men in Western Europe. J Hepatol. 2016.


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    2016-11-02 柳叶一刀
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    2016-11-02 gwc384
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    2016-11-01 保守主义

    继续学习~

    0

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    2016-11-01 保守主义

    有意思~

    0

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    2016-11-01 漪佩飞飞

    好的很好的很好的!!!

    0

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