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Clin Gastroenterol H:吸烟和饮酒与无柄锯齿状息肉的关系

2018-12-03 xing.T MedSci原创

由此可见,在结肠镜检查数据库的分析中,研究人员发现,在无症状的年轻人中,吸烟和饮酒与任何SSP和较大SSP相关。停止吸烟降低了SSP的风险。因此,可以建议进行早期改变生活方式,以便对年轻人的SSP进行一级预防。

近日,消化病领域权威杂志Clinical Gastroenterology and Hepatology发表了一篇研究文章,该研究的目的是调查无柄锯齿状息肉(SSPs)的患病率以及无症状年轻人中SSP风险与可改变生活方式因素之间的关系。

研究人员使用了包含13618名无症状受试者(30-49岁)和17999名受试者(50-75岁)的结肠镜检查数据库进行了横断面研究,通过对包括吸烟和饮酒在内的临床数据的多变量分析来研究SSP的危险因素。

在30-49岁的受试者中,SSP的患病率为2.0%(275/13618个体)。在所有SSP患者中,40.7%(112/275)的患者息肉较大(≥10mm)。吸烟≥20包年与总体SSP(比值比[OR]为1.87; 95%CI为1.17-2.99)和较大的SSP(OR为3.03; 95%CI为1.62-5.66)相关。解剖位置与≥20包年吸烟之间的关联在远端SSP中强于近端SSP(OR为2.71; 95%CI为1.27-5.77 vs. OR为1.60; 95%CI为1.00-2.54)。停止吸烟≥5年可降低SSP(OR为0.49; 95%CI为0.28-0.86)和较大SSP(OR为0.23; 95%CI为0.10-0.54)的风险。酒精摄入与较大SSP有关。对于50-75岁的受试者,这些结果是相似的。

由此可见,在结肠镜检查数据库的分析中,研究人员发现,在无症状的年轻人中,吸烟和饮酒与任何SSP和较大SSP相关。停止吸烟降低了SSP的风险。因此,可以建议进行早期改变生活方式,以便对年轻人的SSP进行一级预防

原始出处:

Ji Young Lee,et al.Association Between Cigarette Smoking and Alcohol Consumption and Sessile Serrated Polyps in Subjects 30 to 49 Years Old. Clinical gastroenterology and hepatology.2018.https://www.cghjournal.org/article/S1542-3565(18)31277-1/fulltext

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