BMJ：mRNA-1273接种后中青年，BNT162b2接种后女性心肌炎心包炎风险增加

2021-12-20 MedSci原创 MedSci原创

接种mRNA-1273疫苗导致心肌炎或心包炎风险增加，特别是12-39岁中青年人群，而接种BNT162b2疫苗后，女性心肌炎或心包炎风险增加

药物警戒报告、卫生系统监测和病例研究均表明，Sars-cov-2疫苗接种与心肌炎或心包炎有关，特别是接种了mRNA疫苗BNT162b2和mRNA-1273第二剂之后。在最严重的情况下，心肌炎或心包炎可导致慢性心力衰竭或死亡，是重要的安全问题，但其生物学机制尚不清楚，同样的不良事件也发现在成人接受天花疫苗接种后。近日研究人员开展以人群为基础的队列研究考察了Sars-cov-2mRNA疫苗接种后的心肌炎和心包炎风险。

本次研究在丹麦开展，包含2020年10月1日至2021年10月5日期间，4931775 名12岁以上参与者。研究的主要终点为心肌炎或心包炎，定义为医院诊断为心肌炎或心包炎，肌钙蛋白水平升高，住院时间持续24小时以上。。

在随访期间，269人出现心肌炎或心包炎，其中108人（40%）年龄在12-39岁，196人（73%）为男性。在3482295名接种了BNT162b2疫苗人群中，48人在接种日期后28天内发生心肌炎或心包炎，与未接种人群心肌炎或心包炎发病率相比，接种疫苗后的心肌炎或心包炎风险为1.34，疫苗接种人群的绝对心肌炎或心包炎风险为每10万名接种者1.4人。女性和男性接种者的调整风险比分别为3.73和0.82，绝对风险分别为每10万人1.3和1.5例。12-39岁人群的调整风险为1.48，绝对风险为每10万人1.6例。在498814名接种了mRNA-1273疫苗人群中，21人在接种日期后28天内发生心肌炎或心包炎，与未接种人群心肌炎或心包炎发病率相比，接种疫苗后的心肌炎或心包炎风险为3.92，疫苗接种人群的绝对心肌炎或心包炎风险为每10万名接种者4.2人。女性和男性接种者的调整风险比分别为6.33和3.22，绝对风险分别为每10万人2.0和6.3例。12-39岁人群的调整风险为5.24，绝对风险为每10万人5.7例。

第二剂mRNA疫苗接种后心肌炎或心包炎风险增加

基于丹麦人口的队列研究发现，接种mRNA-1273疫苗导致心肌炎或心包炎风险增加，特别是12-39岁中青年人群，而接种BNT162b2疫苗后，女性心肌炎或心包炎风险增加，但接种SARS-CoV-2 mRNA疫苗后心肌炎或心包炎的绝对风险仍是较低水平的。

原始出处：

Anders Husby et al. SARS-CoV-2 vaccination and myocarditis or myopericarditis： population based cohort study. BMJ，December 16，2021

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2022-10-01 liao1619

#mRNA-1273#

62 0
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2022-03-16 gaoxiaoe

#BMJ#

76 0
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2021-12-22 zhao4617

#心包炎#

87 0
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2021-12-22 xuyu

#中青年#

72 0
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2021-12-21 查查佳佳

是一年过去了，一年一度的中科院分区也来

92 0
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2021-12-21 学医无涯

学习一下

92 0
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2021-12-20 1561fd8b97m

那是什么原因导致的

78 0
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2021-12-20 杏林小小

#mRNA-1273#

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