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AAAAI 2016:慢性鼻窦炎鼻息肉患者常出现阿司匹林加重性呼吸系统疾病

2016-04-19 MedSci MedSci原创

据美国过敏、哮喘和免疫学会2016年会上展示的一项新的研究显示, 16%的慢性鼻窦炎鼻息肉患者可出现阿司匹林加重性呼吸系统疾病,且阿司匹林加重性呼吸系统疾病与更重疾病的发生有关。

据美国过敏、哮喘和免疫学会2016年会上展示的一项新的研究显示, 16%的慢性鼻窦炎鼻息肉患者可出现阿司匹林加重性呼吸系统疾病,且阿司匹林加重性呼吸系统疾病与更重疾病的发生有关。

“阿司匹林加重性呼吸系统疾病(AERD)包括慢性鼻窦炎伴鼻息肉(CRSwNP),哮喘和不耐受COX-1酶抑制剂(如阿司匹林)三联征,”来自西北大学费因伯格医学院的Whitney W. Stevens博士说道,“AERD的患病率仍不清楚,很少有研究对比了AERD患者与不伴有CRS的CRSwNP或哮喘患者的临床特征。”

该研究中,通过搜索一家三级医疗中心的电子医疗记录Stevens及其同事确定了459名CRSwNP患者,同时存在CRSwNP和哮喘的412名患者以及173名AERD患者。使用相同的医疗记录,研究人员建立了一个对照组,包括300名哮喘患者,以评估其肺功能,鼻窦手术和口服糖皮质激素的使用。

16%的仅存在CRSwNP的患者出现了AERD。与仅存在CRSwNP的患者相比, AERD患者接受鼻窦手术的次数为其二倍,且年龄平均年轻3岁。

此外,研究人员发现,83% 的AERD患者出现特应性反应, 85%的哮喘患者出现特应性反应,但是仅有66%的CRSwNP患者出现特应性反应。与哮喘患者相比,AERD患者的FEV1较低(80% vs 86%)。

13%的AERD患者存在皮质类固醇激素依赖性疾病,而仅有4%同时存在鼻息肉和哮喘的患者存在此疾病,而对于哮喘患者仅有 1%的患者存在此疾病。

最后,Stevens 说道,“这是对比了手术和非手术治疗的AERD患者与CRSwNP患者和哮喘患者的最大型研究中的一个研究。”

原始出处:

Will Offit. Aspirin-exacerbated respiratory disease common in chronic rhinosinusitis with nasal polyps. Healio, April 2016.

Stevens WW, et al. Abstract 210. Presented at: American Academy of Allergy, Asthma & Immunology Annual Meeting; March 4-7, 2016; Los Angeles.

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    2016-09-11 doctorJiangchao

    继续学习

    0

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    2016-09-11 doctorJiangchao

    继续关注

    0

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    2016-08-26 ylzr123

    深度好文,赞一个!!!

    0

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    2016-07-28 刘煜

    学习新知识,增长新见识。

    0

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    2017-03-09 ay2000fy
  6. [GetPortalCommentsPageByObjectIdResponse(id=122438, encodeId=0d5c12243876, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Sep 11 11:10:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=122440, encodeId=96f212244023, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sun Sep 11 11:10:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104776, encodeId=2c98104e76f5, content=深度好文,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 26 14:35:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=94932, encodeId=04d3949325a, content=学习新知识,增长新见识。, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Jul 28 15:05:00 CST 2016, time=2016-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995742, encodeId=25411995e42c2, content=<a href='/topic/show?id=edd21655a4' target=_blank style='color:#2F92EE;'>#AAA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1655, encryptionId=edd21655a4, topicName=AAA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Thu Mar 09 14:15:00 CST 2017, time=2017-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351377, encodeId=ddb413513e76c, content=<a href='/topic/show?id=be7453e38d2' target=_blank style='color:#2F92EE;'>#慢性鼻窦炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53738, encryptionId=be7453e38d2, topicName=慢性鼻窦炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Apr 21 10:15:00 CST 2016, time=2016-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418997, encodeId=7b18141899e50, content=<a href='/topic/show?id=ab4d3969143' target=_blank style='color:#2F92EE;'>#呼吸系统疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39691, encryptionId=ab4d3969143, topicName=呼吸系统疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75de3457664, createdName=医生2395, createdTime=Thu Apr 21 10:15:00 CST 2016, time=2016-04-21, status=1, ipAttribution=)]
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