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JAMA:老年患者皮肤及口腔红斑病损伴体重减轻-病例分析

2015-02-19 MedSci MedSci原创

一位74岁英籍男子,4月前发现口腔及颈部、胸部、腹部、上肢处出现暗红色病变,并逐渐增多。在这期间曾到血液科、皮肤科、心内科就诊,被诊断为因华法林抗凝治疗引起的皮肤粘膜瘀斑。患者无恶性肿瘤病史及传染病史。在过去的这几个月里,患者体重减轻15.8kg,否认发烧和夜间盗汗。体格检查发现颈部、躯干及双侧上肢皮肤可见大量微凸的红斑状结节,口内检查可见软腭部存在两处类圆形边界清晰的红色斑块。其余检查未见异常。

一位74岁英籍男子,4月前发现口腔及颈部、胸部、腹部、上肢处出现暗红色病变,并逐渐增多。在这期间曾到血液科、皮肤科、心内科就诊,被诊断为因华法林抗凝治疗引起的皮肤粘膜瘀斑。患者无恶性肿瘤病史及传染病史。在过去的这几个月里,患者体重减轻15.8kg,否认发烧和夜间盗汗。体格检查发现颈部、躯干及双侧上肢皮肤可见大量微凸的红斑状结节,口内检查可见软腭部存在两处类圆形边界清晰的红色斑块。其余检查未见异常。实验室检查结果显示凝血酶原时间为11.6s,国际标准化比值为1,血红蛋白12.1g/dL,血小板计数106×103/μL;肝功能检查各数值结果均在正常范围内。对皮肤病灶进行活检检查,等待病理结果。下一步应做何种检查或治疗?A. 根据经验采用类固醇外用药物治疗B. 采用光动力疗法C. 行胸部、腹部、骨盘的 CT 检查D.行HIV检查诊断 卡波西肉瘤下一步的检查D.行HIV检查该病例的主要临床特点是多灶性红斑结节伴有原因不明的体重减轻,加上不明确的 HIV感染史,这就提高了对卡波西肉瘤的诊断。尽管患者的年龄与经典的卡波西肉瘤相符,但体重减轻明显以及发生在上肢而不是下肢的病损与经典的卡波西肉瘤不大相

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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=125416, encodeId=5b3512541684, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 14:37:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16669, encodeId=9ccf16669c8, content=这个世界太吓人了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=ixiaochengdudu, createdTime=Sat Feb 21 16:29:00 CST 2015, time=2015-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407219, encodeId=488e140e21924, content=<a href='/topic/show?id=dc4b26688c5' target=_blank style='color:#2F92EE;'>#体重减轻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26688, encryptionId=dc4b26688c5, topicName=体重减轻)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ee42614858, createdName=whlxd, createdTime=Sat Feb 21 02:27:00 CST 2015, time=2015-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436058, encodeId=47b8143605815, content=<a href='/topic/show?id=22f8e71238d' target=_blank style='color:#2F92EE;'>#红斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77123, encryptionId=22f8e71238d, topicName=红斑)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Feb 21 02:27:00 CST 2015, time=2015-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16475, encodeId=6f64164e541, content=艾滋病口腔表现太多了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=ixiaochengdudu, createdTime=Thu Feb 19 15:20:00 CST 2015, time=2015-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16464, encodeId=14541646415, content=长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Thu Feb 19 13:16:00 CST 2015, time=2015-02-19, status=1, ipAttribution=)]
    2015-02-21 ixiaochengdudu

    这个世界太吓人了?

    0

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    2015-02-21 zhouqu_8
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    2015-02-19 ixiaochengdudu

    艾滋病口腔表现太多了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=125416, encodeId=5b3512541684, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 14:37:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16669, encodeId=9ccf16669c8, content=这个世界太吓人了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=ixiaochengdudu, createdTime=Sat Feb 21 16:29:00 CST 2015, time=2015-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407219, encodeId=488e140e21924, content=<a href='/topic/show?id=dc4b26688c5' target=_blank style='color:#2F92EE;'>#体重减轻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26688, encryptionId=dc4b26688c5, topicName=体重减轻)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ee42614858, createdName=whlxd, createdTime=Sat Feb 21 02:27:00 CST 2015, time=2015-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436058, encodeId=47b8143605815, content=<a href='/topic/show?id=22f8e71238d' target=_blank style='color:#2F92EE;'>#红斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77123, encryptionId=22f8e71238d, topicName=红斑)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Feb 21 02:27:00 CST 2015, time=2015-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16475, encodeId=6f64164e541, content=艾滋病口腔表现太多了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=ixiaochengdudu, createdTime=Thu Feb 19 15:20:00 CST 2015, time=2015-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16464, encodeId=14541646415, content=长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Thu Feb 19 13:16:00 CST 2015, time=2015-02-19, status=1, ipAttribution=)]
    2015-02-19 午夜星河

    长知识

    0

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