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PLoS Biol:科学家掌握HIV变化属性,解决艾滋病不再是场梦

2017-04-07 Heather_z727 medicalxpress

【“金融计算法”准确算出HIV病毒变化过程,或能将艾滋病扼杀在摇篮中】金融数学(股票价格预测)和粒子的液体扩散可以生成更好的HIV疫苗?根据爱荷华大学的微生物学家希勒尔哈伊姆的说法,我们可以使用概念预测HIV表面蛋白质的进化,得到的信息可以用来设计更加优良的HIV疫苗。人类免疫缺陷病毒1型(HIV-1)是全球艾滋病流行的原因,据世界卫生组织统计,自1970年末,感染艾滋病的人数超过7000万,其中


【“金融计算法”准确算出HIV病毒变化过程,或能将艾滋病扼杀在摇篮中】金融数学(股票价格预测)和粒子的液体扩散可以生成更好的HIV疫苗?根据爱荷华大学的微生物学家希勒尔哈伊姆的说法,我们可以使用概念预测HIV表面蛋白质的进化,得到的信息可以用来设计更加优良的HIV疫苗。

人类免疫缺陷病毒1型(HIV-1)是全球艾滋病流行的原因,据世界卫生组织统计,自1970年末,感染艾滋病的人数超过7000万,其中死于艾滋病的人数已经达到3500万。

“HIV是一个高度动态的病毒,它在持续变化着,我们在研制疫苗的时候,我们试图模仿病毒,这样的话,免疫系统就能学会如何攻击真正的病毒。这项研究的问题就在于如何研制一个不断改变和变化的目标呢?”

这一移动的目标,包膜糖蛋白就位于HIV的表面,这种蛋白质变异频繁,也就是这种多样性使HIV疫苗总是以失败告终,为了研制出适合病毒不断发展特征的疫苗,科学家需要了解包膜糖蛋白变体如何体内循环。研究团队使用预测股票价格的变化的金融计算法,能够准确计算出在过去30年里包膜糖蛋白的进化和变化的过程。

希勒尔哈伊姆表示:“在研究病毒例子扩散的过程中,我们放大了十年来病毒的变化过程,这就是扩散呀!通过研究30年来的病例样本,我们发现了包膜糖蛋白的变化属性,可以用来预测其接下来的变化,这样就可以制定在全世界范围内,适宜不同人群的HIV病毒了。”

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    2021-11-09 湘雅科教

    已拜读,受益匪浅。

    0

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    2018-01-27 sunylz
  3. [GetPortalCommentsPageByObjectIdResponse(id=1068489, encodeId=12f01068489b0, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:34:36 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917424, encodeId=f322191e42442, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jan 27 02:31:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242575, encodeId=89692425e596, content=加油.加油.加油.期待你们的研究成果早日进去临床试验, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c6c2144166, createdName=1861ff86b0m, createdTime=Sun Sep 10 18:10:42 CST 2017, time=2017-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767089, encodeId=bad11e67089f5, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Thu Feb 01 19:31:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186042, encodeId=26d118604216, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/03/22/9492b0bdd3ebdf662ab1cde6e8473dca.jpg, createdBy=0f261679513, createdName=万里江山一孤舟, createdTime=Sat Apr 08 21:17:24 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185999, encodeId=7a191859992e, content=学习了,很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=101c2041447, createdName=1881e9c2b1m, createdTime=Sat Apr 08 14:58:43 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185955, encodeId=9ae4185955dc, content=厉害了,多少病人的希望啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sat Apr 08 09:49:04 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185862, encodeId=d6961858620a, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Apr 08 00:06:13 CST 2017, time=2017-04-08, status=1, ipAttribution=)]
    2017-09-10 1861ff86b0m

    加油.加油.加油.期待你们的研究成果早日进去临床试验

    0

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    2017-04-08 万里江山一孤舟

    学习了

    0

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    2017-04-08 1881e9c2b1m

    学习了,很有用

    0

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    2017-04-08 医艺依意

    厉害了,多少病人的希望啊

    0

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    2017-04-08 飛歌

    学习了很有用

    0

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