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The Lancet:2型糖尿病患者戒烟后风险更高?

2015-04-30 MedSci MedSci原创

    吸烟会增加患2型糖尿病的风险。然而,一些人口研究还表明,吸烟者戒烟3 - 5年后比继续吸烟者风险更高。经过10 - 12年的风险等同于从不吸烟者。小型队列研究表明,糖尿病患者控制在戒烟后的第一年暂时恶化。我们在一项人口研究中检测戒烟是否与糖尿病控制相关联,这种关联多久持续存在,并且这种关联是否是由重量变化介导的。    为此,我们使用健康促进网络(T

吸烟会增加患2型糖尿病的风险。然而,一些人口研究还表明,吸烟者戒烟3 - 5年后比继续吸烟者风险更高。经过10 - 12年的风险等同于从不吸烟者。小型队列研究表明,糖尿病患者控制在戒烟后的第一年暂时恶化。我们在一项人口研究中检测戒烟是否与糖尿病控制相关联,这种关联多久持续存在,并且这种关联是否是由重量变化介导的。
 
为此,我们使用健康促进网络(THIN)对成年吸烟者并患2型糖尿病的患者做了一个回顾性队列研究(从2005年1月1日到2010年12月31日),THIN是一个大型的英国初级保健数据库。我们开发了多层次的调整回归模型来研究戒烟事件,吸烟禁欲时间,糖化血红蛋白的变化和体重变化影响之间的联系。
 
10692名成年吸烟2型糖尿病患者参与了此项研究。 3131名(29%)戒烟并且保持禁欲至少1年。调整潜在混杂因素后,戒烟后第一年中糖化血红蛋白增加了0.21%(95%Cl 0.17-0.25,P<0.001;[2.34毫摩尔/摩尔(95%Cl 1.91-2.77)])。糖化血红蛋白降低禁欲,并继续在3年后和持续吸烟者相媲美。这种增加的HbA1c不是由重量变化介导的。
 
在2型糖尿病中,戒烟与持续3年血糖控制恶化有关,与体重增加无关。在一个人口水平,这暂时升高可能会增加微血管并发症。
 
原始出处
 
Dr Deborah Lycett, PhDcorrespondenceemail, Linda Nichols, PhD, Ronan Ryan, PhD, Amanda Farley, PhD, Andrea Roalfe, MSc, Prof Mohammed A Mohammed, PhD, Lisa Szatkowski, PhD, Prof Tim Coleman, MD, Prof Richard Morris, PhD, Prof Andrew Farmer, DM, Prof Paul Aveyard, PhD,The association between smoking cessation and glycaemic control in patients with type 2 diabetes,The Lancet,2015,4,29

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    2016-01-27 howi
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    2015-05-03 sky0909

    0

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    2015-05-03 sky0909

    0

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