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Neurology: 脑血管反应性可能与脑白质疾病相关

2016-11-05 MedSci MedSci原创

目的;比较有无脑血管反应性(CVR)受损且白质正常(NVWM)的区域,MRI的弥散和灌注的特征。方法:75名中重度脑白质疏松症患者,应用3T磁共振成像系统使用精确的二氧化碳刺激操作来检查血氧水平依赖CVR图像。应用方差分析比较有无CVR受损的NVWM区域的MRI特征,并应用Bonferroni校正多重比较。结果: CVR受损的NAWM区与各向异性分数平均降低(SD)3.7%(2.4),脑血流量降低

目的:比较有无脑血管反应性(CVR)受损且白质正常(NVWM)的区域,MRI的弥散和灌注的特征。

方法:75名中重度脑白质疏松症患者,应用3T磁共振成像系统使用精确的二氧化碳刺激操作来检查血氧水平依赖CVR图像。应用方差分析比较有无CVR受损的NVWM区域的MRI特征,并应用Bonferroni校正多重比较。

结果: CVR受损的NAWM区与各向异性分数平均降低(SD)3.7%(2.4),脑血流量降低22.1%(8.2),局部脑血容量降低22.2%(7),平均扩散率增加3.9%(3.1),开始到最大值的时间增加10.9%(13.2)(P<0.01)相关。

结论:应用几种MRI定量弥散和灌注指标评价,CVR受损与NAWM区组织的完整性微妙变化相关。这些结果表明,CVR损伤可能有助于脑白质病的进展。

原始出处:

Sam K, Peltenburg B, et al. Cerebrovascular reactivity and white matter integrity Neurology. 2016 Oct 28.

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    2017-10-05 yinhl1978
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