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临床研究中最小临床意义变化值（MCID）确定方法

2012-12-13 MedSci MedSci原创

MCID最小临床意义变化值统计
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目前确定最小临床意义变化值（minimal clinically important difference，MCID)的方法有效标法、分布法、专家意见法和文献分析法。效标法可对所确定的最小临床意义变化值给出专业解释,但没有考虑测量误差, 不同效标会产生不同的最小临床意义变化值,而且通常情况下很难找到合适的效标。分布法考虑了测量误差,易于实施,但不同样本得出的结果可能不同,无法为所 确定的最小可

目前确定最小临床意义变化值（minimal clinically important difference，MCID)的方法有效标法、分布法、专家意见法和文献分析法。效标法可对所确定的最小临床意义变化值给出专业解释,但没有考虑测量误差, 不同效标会产生不同的最小临床意义变化值,而且通常情况下很难找到合适的效标。分布法考虑了测量误差,易于实施,但不同样本得出的结果可能不同,无法为所 确定的最小可测变化值给出专业解释,对得出的最小可测变化值缺乏公认的判断准则。专家意见法和文献分析法则分别基于专家意见和已发表文献,只能作为辅助。 在确定最小临床意义变化值时,最好能综合使用效标法、分布法和专家意见法。全文下载： 临床研究中最小临床意义变化值（MCID）确定方法

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评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2218743, encodeId=3a0b2218e43f4, content=<a href='/topic/show?id=c6a4113e972' target=_blank style='color:#2F92EE;'>#MCID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11379, encryptionId=c6a4113e972, topicName=MCID)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=72509412783, createdName=ms4000000796991224, createdTime=Tue Aug 06 11:47:26 CST 2024, time=2024-08-06, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=1991544, encodeId=178c199154475, content=<a href='/topic/show?id=f88a4e047f' target=_blank style='color:#2F92EE;'>#CID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4704, encryptionId=f88a4e047f, topicName=CID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Thu Feb 21 22:04:00 CST 2013, time=2013-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5325, encodeId=a4385325d8, content=这个很不错，要是可以提供摘要就更好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5ce75636, createdName=csjlsh, createdTime=Mon Jan 07 19:12:00 CST 2013, time=2013-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519378, encodeId=8f0715193e8d4, content=<a href='/topic/show?id=3731113e8c3' target=_blank style='color:#2F92EE;'>#MCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11378, encryptionId=3731113e8c3, topicName=MCI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=934111256894, createdName=hukaixun, createdTime=Sat Dec 15 09:04:00 CST 2012, time=2012-12-15, status=1, ipAttribution=)]
    2024-08-06 ms4000000796991224 来自江苏省

    #MCID#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2218743, encodeId=3a0b2218e43f4, content=<a href='/topic/show?id=c6a4113e972' target=_blank style='color:#2F92EE;'>#MCID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11379, encryptionId=c6a4113e972, topicName=MCID)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=72509412783, createdName=ms4000000796991224, createdTime=Tue Aug 06 11:47:26 CST 2024, time=2024-08-06, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=1991544, encodeId=178c199154475, content=<a href='/topic/show?id=f88a4e047f' target=_blank style='color:#2F92EE;'>#CID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4704, encryptionId=f88a4e047f, topicName=CID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Thu Feb 21 22:04:00 CST 2013, time=2013-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5325, encodeId=a4385325d8, content=这个很不错，要是可以提供摘要就更好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5ce75636, createdName=csjlsh, createdTime=Mon Jan 07 19:12:00 CST 2013, time=2013-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519378, encodeId=8f0715193e8d4, content=<a href='/topic/show?id=3731113e8c3' target=_blank style='color:#2F92EE;'>#MCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11378, encryptionId=3731113e8c3, topicName=MCI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=934111256894, createdName=hukaixun, createdTime=Sat Dec 15 09:04:00 CST 2012, time=2012-12-15, status=1, ipAttribution=)]
    2013-02-21 xlxchina

    #CID#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2218743, encodeId=3a0b2218e43f4, content=<a href='/topic/show?id=c6a4113e972' target=_blank style='color:#2F92EE;'>#MCID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11379, encryptionId=c6a4113e972, topicName=MCID)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=72509412783, createdName=ms4000000796991224, createdTime=Tue Aug 06 11:47:26 CST 2024, time=2024-08-06, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=1991544, encodeId=178c199154475, content=<a href='/topic/show?id=f88a4e047f' target=_blank style='color:#2F92EE;'>#CID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4704, encryptionId=f88a4e047f, topicName=CID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Thu Feb 21 22:04:00 CST 2013, time=2013-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5325, encodeId=a4385325d8, content=这个很不错，要是可以提供摘要就更好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5ce75636, createdName=csjlsh, createdTime=Mon Jan 07 19:12:00 CST 2013, time=2013-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519378, encodeId=8f0715193e8d4, content=<a href='/topic/show?id=3731113e8c3' target=_blank style='color:#2F92EE;'>#MCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11378, encryptionId=3731113e8c3, topicName=MCI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=934111256894, createdName=hukaixun, createdTime=Sat Dec 15 09:04:00 CST 2012, time=2012-12-15, status=1, ipAttribution=)]
    2013-01-07 csjlsh

    这个很不错，要是可以提供摘要就更好了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2218743, encodeId=3a0b2218e43f4, content=<a href='/topic/show?id=c6a4113e972' target=_blank style='color:#2F92EE;'>#MCID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11379, encryptionId=c6a4113e972, topicName=MCID)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=72509412783, createdName=ms4000000796991224, createdTime=Tue Aug 06 11:47:26 CST 2024, time=2024-08-06, status=1, ipAttribution=江苏省), GetPortalCommentsPageByObjectIdResponse(id=1991544, encodeId=178c199154475, content=<a href='/topic/show?id=f88a4e047f' target=_blank style='color:#2F92EE;'>#CID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4704, encryptionId=f88a4e047f, topicName=CID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Thu Feb 21 22:04:00 CST 2013, time=2013-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5325, encodeId=a4385325d8, content=这个很不错，要是可以提供摘要就更好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5ce75636, createdName=csjlsh, createdTime=Mon Jan 07 19:12:00 CST 2013, time=2013-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519378, encodeId=8f0715193e8d4, content=<a href='/topic/show?id=3731113e8c3' target=_blank style='color:#2F92EE;'>#MCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11378, encryptionId=3731113e8c3, topicName=MCI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=934111256894, createdName=hukaixun, createdTime=Sat Dec 15 09:04:00 CST 2012, time=2012-12-15, status=1, ipAttribution=)]
    2012-12-15 hukaixun

    #MCI#

    0

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