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JAMA Surgery:NSM可有效降低BRCA突变人群乳腺癌风险

2017-09-24 佚名 肿瘤资讯

保留乳头的全乳切除术(NSM)可有效降低BRCA突变人群乳腺癌风险。

保留乳头的全乳切除术(NSM)可有效降低BRCA突变人群乳腺癌风险。


该多中心回顾性研究纳入了为了减少风险而接受对侧乳房切除术的乳腺癌患者,主要结局指标为预防性NSM后出现新的乳腺癌。中位随访34个月,分别有58.4%及41.6%接受了双侧或单侧预防性 NSM;BRCA1或BRCA2突变患者分别为201例及145例;所有预防性NSM后未发生同侧乳腺癌,双侧预防性NSM后未发生任何乳腺癌;用BRCA1/2突变携带者风险模型推算,如果不接受预防性NSM可有大约22例新的原发性乳腺癌;预防性NSM可使乳腺癌事件显着减少。

原始出处:
[2]James W.Jakub,MD; Anne WarrenPeled,MD; Richard J.Gray,MD.et al.Oncologic Safety of Prophylactic Nipple-Sparing Mastectomy in a Population With BRCA Mutations: A Multi-institutional Study.JAMA Surg. 2017 Sep 13. [Epub ahead of print]

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    2018-08-08 chg121
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likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4Cr8ibeWnmTmmC1lthicNVicicXTX7Mn9OEib5S1eHg4jhM9usWmW2NBVm6NaJurhgeMl3UJ1gujuaQuIX7icVSa8F4JoFPCfib0Prsk/0, createdBy=b5bb2069360, createdName=cherry bomb, createdTime=Mon Sep 25 06:54:44 CST 2017, time=2017-09-25, status=1, ipAttribution=)]
    2017-11-10 1771ae4158m

    学习一下很不错

    0

  5. 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likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4Cr8ibeWnmTmmC1lthicNVicicXTX7Mn9OEib5S1eHg4jhM9usWmW2NBVm6NaJurhgeMl3UJ1gujuaQuIX7icVSa8F4JoFPCfib0Prsk/0, createdBy=b5bb2069360, createdName=cherry bomb, createdTime=Mon Sep 25 06:54:44 CST 2017, time=2017-09-25, status=1, ipAttribution=)]
    2017-11-10 1771ae4158m

    学习一下很不错

    0

  6. 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likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4Cr8ibeWnmTmmC1lthicNVicicXTX7Mn9OEib5S1eHg4jhM9usWmW2NBVm6NaJurhgeMl3UJ1gujuaQuIX7icVSa8F4JoFPCfib0Prsk/0, createdBy=b5bb2069360, createdName=cherry bomb, createdTime=Mon Sep 25 06:54:44 CST 2017, time=2017-09-25, status=1, ipAttribution=)]
    2017-11-25 sjq027
  7. 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likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4Cr8ibeWnmTmmC1lthicNVicicXTX7Mn9OEib5S1eHg4jhM9usWmW2NBVm6NaJurhgeMl3UJ1gujuaQuIX7icVSa8F4JoFPCfib0Prsk/0, createdBy=b5bb2069360, createdName=cherry bomb, createdTime=Mon Sep 25 06:54:44 CST 2017, time=2017-09-25, status=1, ipAttribution=)]
    2017-09-28 luominglian113

    学习了.谢谢分享

    0

  8. 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  9. 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topicName=null, topicId=null, topicList=[TopicDto(id=3703, encryptionId=39fd3e036a, topicName=BRCA突变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=793f3344126, createdName=zhanglin3080, createdTime=Tue Sep 26 12:06:00 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1594020, encodeId=7558159402021, content=<a href='/topic/show?id=63cc368459' target=_blank style='color:#2F92EE;'>#BRCA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3684, encryptionId=63cc368459, topicName=BRCA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Tue Sep 26 12:06:00 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247473, encodeId=5d7124e47302, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4Cr8ibeWnmTmmC1lthicNVicicXTX7Mn9OEib5S1eHg4jhM9usWmW2NBVm6NaJurhgeMl3UJ1gujuaQuIX7icVSa8F4JoFPCfib0Prsk/0, createdBy=b5bb2069360, createdName=cherry bomb, createdTime=Mon Sep 25 06:54:44 CST 2017, time=2017-09-25, status=1, ipAttribution=)]
    2017-09-26 智智灵药
  10. 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    2017-09-25 cherry bomb

    学习了谢谢分享

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