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Acta Biomater:骨再生3D支架的设计与性能

2018-01-28 MedSci MedSci原创

在这项研究中,采用泰森多边形图设计新颖的骨三维(3D)多孔支架。采用计算机设计软件对泰森多边形法进行处理获得3D虚拟各向同性多孔互连模型,与骨小梁主要组织形态学指标(骨小梁厚度、骨小梁间距、小梁数量、骨体积与总体积比、骨面积与骨量比率等)完全匹配。对于机械(弹性模量)和流体质量输送(渗透性)性质,这些类似骨的模型已被进一步计算。结果表明,支架的最终性能可以在其微观结构和组织形态学初始设计阶段进行控

在这项研究中,采用泰森多边形图设计新颖的骨三维(3D)多孔支架。采用计算机设计软件对泰森多边形法进行处理获得3D虚拟各向同性多孔互连模型,与骨小梁主要组织形态学指标(骨小梁厚度、骨小梁间距、小梁数量、骨体积与总体积比、骨面积与骨量比率等)完全匹配。对于机械(弹性模量)和流体质量输送(渗透性)性质,这些类似骨的模型已被进一步计算。

结果表明,支架的最终性能可以在其微观结构和组织形态学初始设计阶段进行控制。这也表明,最终的特性可以在设计阶段进行调整,以完全符合骨小梁天然骨。此外,相同的总孔隙度模型可以被设计为具有完全不同的特定骨表面积,因此,这种特定的微结构特征可以用于有利于细胞粘附、迁移以及最终新骨的形成(即骨传导)。

综上所述,该研究结果表明,一旦虚拟模型被充分表征和优化,这些可以通过增材制造和/或立体成像技术容易地进行3D打印。

原始出处:

Gómez S, Vlad MD, López J, Fernández E. Design and properties of 3D scaffolds for bone tissue engineering. Acta Biomater. 2016 Sep 15;42:341-350. doi: 10.1016/j.actbio.2016.06.032. Epub 2016 Jun 28.

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    2018-12-31 sunylz
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    2018-11-24 windight
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    2018-01-30 lsj630
  5. [GetPortalCommentsPageByObjectIdResponse(id=1917908, encodeId=dc82191e908b6, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Dec 31 04:53:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849583, encodeId=25ad184958365, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sat Nov 24 11:53:00 CST 2018, time=2018-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336025, encodeId=f87d1336025d0, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Tue Jan 30 05:53:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472109, encodeId=9e2514e2109d2, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Tue Jan 30 05:53:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282971, encodeId=07852829e1a3, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Sun Jan 28 20:02:38 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282910, encodeId=c1bb282910ef, content=^_^^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Sun Jan 28 16:09:13 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282885, encodeId=c70c28288524, content=采用计算机设计软件对泰森多边形法进行处理获得3D虚拟各向同性多孔互连模型.与骨小梁主要组织形态学指标(骨小梁厚度.骨小梁间距.小梁数量.骨体积与总体积比.骨面积与骨量比率等)完全匹配, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Jan 28 15:25:58 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-28 137****9095

    henhao

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1917908, encodeId=dc82191e908b6, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Dec 31 04:53:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849583, encodeId=25ad184958365, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sat Nov 24 11:53:00 CST 2018, time=2018-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336025, encodeId=f87d1336025d0, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Tue Jan 30 05:53:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472109, encodeId=9e2514e2109d2, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Tue Jan 30 05:53:00 CST 2018, time=2018-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282971, encodeId=07852829e1a3, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=353a2047758, createdName=137****9095, createdTime=Sun Jan 28 20:02:38 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282910, encodeId=c1bb282910ef, content=^_^^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Sun Jan 28 16:09:13 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282885, encodeId=c70c28288524, content=采用计算机设计软件对泰森多边形法进行处理获得3D虚拟各向同性多孔互连模型.与骨小梁主要组织形态学指标(骨小梁厚度.骨小梁间距.小梁数量.骨体积与总体积比.骨面积与骨量比率等)完全匹配, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Jan 28 15:25:58 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-28 wqkm

    ^_^^_^^_^^_^

    0

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    2018-01-28 有备才能无患

    采用计算机设计软件对泰森多边形法进行处理获得3D虚拟各向同性多孔互连模型.与骨小梁主要组织形态学指标(骨小梁厚度.骨小梁间距.小梁数量.骨体积与总体积比.骨面积与骨量比率等)完全匹配

    0

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