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NEJM:软式乙状结肠镜检查减少结直肠癌发病和死亡(PLCO研究)

2012-05-24 卢秀玲 爱唯医学网

       PLCO试验结果显示,与接受常规检查相比,每3或5年接受1次软式乙状结肠镜检查的男性和女性结直肠癌发病率下降21%,总结直肠癌死亡率和远端结直肠癌死亡率分别下降26%和50%。 (查看文献)        在该项大规模随机对照试验中,匹斯堡大学医学中心的Robert E. Schoen博士及其同事随

       PLCO试验结果显示,与接受常规检查相比,每3或5年接受1次软式乙状结肠镜检查的男性和女性结直肠癌发病率下降21%,总结直肠癌死亡率和远端结直肠癌死亡率分别下降26%和50%。 (查看文献)        在该项大规模随机对照试验中,匹斯堡大学医学中心的Robert E. Schoen博士及其同事随机对154,900例年龄55~74岁的男性和女性基线时行软式乙状结肠镜检查,且每3或5年复查1次(77,445例)或常规检查(77,455例),后者定义为“由医生建议的各种检查”。各组男女均等,半数以上(64%)年龄在55~64岁,86%为白人(非西班牙裔),34%为大学毕业生。干预组和常规检查组除方案规定的筛查外,常规结肠镜检查率分别为47.7%和48.0%。中位随访时间11.9年,收集有关随访、癌症诊断和癌症并发症等资料。主要终点为结直肠癌死亡率,次要终点为结直肠癌发病率。        随访期间,干预组和常规检查组结直肠癌发生率分别为11.9例和15.2

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    2012-05-26 zhouqu_8
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