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JACC:在缺血性和非缺血性心衰患者中,T2DM都可以预测死亡

2016-09-22 MedSci MedSci原创

心衰(HF)是2型糖尿病(T2DM)患者常见和严重的并发症。然而,此类患者的缺血性HF和血管重建的预后还没有很好地被调查。该研究的目的是在一个有和没有T2DM的患者群中,调查缺血性与非缺血HF和以前血运重建对该患者群的长期预后影响。在瑞典心衰注册(SwedeHF)中,研究人员通过糖尿病状态和缺血性或非缺血性HF,以及血运重建史对患者进行分层,研究人员在2003年至2011年期间对这些患者进行了随访

心衰(HF)是2型糖尿病(T2DM)患者常见和严重的并发症。然而,此类患者的缺血性HF和血管重建的预后还没有很好地被调查。

该研究的目的是在一个有和没有T2DM的患者群中,调查缺血性与非缺血HF和以前血运重建对该患者群的长期预后影响。

在瑞典心衰注册(SwedeHF)中,研究人员通过糖尿病状态和缺血性或非缺血性HF,以及血运重建史对患者进行分层,研究人员在2003年至2011年期间对这些患者进行了随访,探讨了这些患者的死亡预测因子和寿命。倾向评分分析用来评估之前血运重建的影响。

在35163例心衰患者中,患有2型糖尿病的患者都较年轻,并且90%的患者有1个或多个相关合并症。T2DM患者的缺血性心脏疾病(IHD)发病率为62%,而无2型糖尿病患者的IHD发病率为47%,在这些患者中,分别有53%和48%的患者经历了血运重建。不管IHD是否存在,T2DM都可以预测死亡,那些有和无IHD患者调整后的危险比(HR)和95%可信区间(CI)分别为1.40(1.33至1.46)和1.30(1.22至1.39)。兼有T2DM和IHD的患者有最高的死亡率,如果没有血运重建,该死亡率会更高(调整后的HR:0.82; 95%CI:0.75至0.91)。倾向评分的调整并没有改变这些结果(HR:0.87; 95%CI:0.78至0.96)。血运重建并没有消除T2DM的影响,在那些有血运重建史(HR:1.36; 95%CI:1.24至1.48)和无血运重建史(HR:1.45; 95%CI:1.33至1.56)的患者中,T2DM都可以预测死亡。

90%的T2DM心衰患者都有可以预防的合并症。在T2DM患者中,IHD对死亡有负面影响,然而这些患者可以受益于之前的血运重建史。

原始出处:

Isabelle Johansson,Ulf Dahlström,Magnus Edner,et al.Prognostic Implications of Type 2 Diabetes Mellitus in Ischemic and Nonischemic Heart Failure,JACC,2016.9.21


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    2017-02-26 hbwxf
  3. 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  4. 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    2016-09-30 jyzxjiangqin

    理论需要实践检验。

    0

  5. 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    2016-09-26 jyzxjiangqin

    缺血和非缺血性心衰患者需要科学治疗。

    0

  6. 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    2016-09-25 doctorJiangchao

    继续学习

    0

  7. 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    2016-09-25 doctorJiangchao

    继续关注

    0

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