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房颤抗凝后为何还会发生中风?日本研究

2020-08-20 xujing 中国循环杂志

近日,Heart杂志发表的纳入11848例房颤患者的日本研究显示,房颤患者即使抗凝治疗有效,缺血性卒中和全身性栓塞的风险仍较高。

近日,Heart杂志发表的纳入11848例房颤患者的日本研究显示,房颤患者即使抗凝治疗有效,缺血性卒中和全身性栓塞的风险仍较高。

DOI:10.1136/heartjnl-2020-317299

研究发现,高龄、高血压和血脂异常是房颤患者抗凝后发生缺血性卒中和全身性栓塞的危险因素。约三分之一的残余风险可归因于高血压、糖尿病和血脂异常。

该研究中,年龄<50岁者服用口服抗凝药的比例为39.1%,50~60岁为56.6%,60~65岁为61.0%,65~75岁为64.4%,抗凝药物的使用随着年龄的增长而增加。

平均随访3年,共发生200例缺血性卒中和全身性栓塞事件,发病率0.57%,仍然明显高于普通人群(0.1%-0.2%)。

在多变量分析中,≥65岁、高血压和血脂异常分别使缺血性卒中和全身性栓塞风险增加1倍、41%和46%。

研究发现,高血压、糖尿病和血脂异常,这三项可改变的危险因素导致的缺血性卒中和全身性栓塞风险占30%。

原始出处:Toshiki Maeda, Takumi Nishi, Shunsuke Funakoshi, et al. Residual risks of ischaemic stroke and systemic embolism among atrial fibrillation patients with anticoagulation: large-scale real-world data (F-CREATE project). Heart. online first, August 14, 2020

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    2022-02-16 ms1000001075812023

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    2020-08-27 14818eb4m67暂无昵称

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    2020-08-22 别克君

    学习

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1194136, encodeId=da9711941364f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=da2a5596356, createdName=ms1000001075812023, createdTime=Wed Feb 16 19:54:05 CST 2022, time=2022-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694822, encodeId=8d481694822d4, content=<a href='/topic/show?id=a7385426313' target=_blank style='color:#2F92EE;'>#房颤抗凝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54263, encryptionId=a7385426313, topicName=房颤抗凝)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8df129768056, createdName=xiongke020, createdTime=Sun Sep 06 09:31:24 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891901, encodeId=f6c589190198, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d65c2218916, createdName=120f372am88暂无昵称, createdTime=Tue Oct 13 22:57:12 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=813836, encodeId=a8528138366a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 08:28:57 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812051, encodeId=19d581205140, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ee15412128, createdName=别克君, createdTime=Sat Aug 22 16:43:44 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294566, encodeId=7831129456617, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Fri Aug 21 16:31:24 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031298, encodeId=ee2b10312988d, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Thu Aug 20 04:31:24 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045977, encodeId=974c10459e785, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Aug 20 04:31:24 CST 2020, time=2020-08-20, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1194136, encodeId=da9711941364f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=da2a5596356, createdName=ms1000001075812023, createdTime=Wed Feb 16 19:54:05 CST 2022, time=2022-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694822, encodeId=8d481694822d4, content=<a href='/topic/show?id=a7385426313' target=_blank style='color:#2F92EE;'>#房颤抗凝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54263, encryptionId=a7385426313, topicName=房颤抗凝)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8df129768056, createdName=xiongke020, createdTime=Sun Sep 06 09:31:24 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891901, encodeId=f6c589190198, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d65c2218916, createdName=120f372am88暂无昵称, createdTime=Tue Oct 13 22:57:12 CST 2020, time=2020-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=813836, encodeId=a8528138366a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 08:28:57 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812051, encodeId=19d581205140, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ee15412128, createdName=别克君, createdTime=Sat Aug 22 16:43:44 CST 2020, time=2020-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294566, encodeId=7831129456617, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Fri Aug 21 16:31:24 CST 2020, time=2020-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031298, encodeId=ee2b10312988d, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Thu Aug 20 04:31:24 CST 2020, time=2020-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045977, encodeId=974c10459e785, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Thu Aug 20 04:31:24 CST 2020, time=2020-08-20, status=1, ipAttribution=)]
    2020-08-20 心介

    房颤,临床上碰到很多哦

    0

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    2020-08-20 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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