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Neurology :类固醇或对治疗食物中毒引发的痉挛昏睡有效

2014-01-20 佚名 生物360

肠出血性大肠杆菌导致食物中毒时,重症患者有时会出现痉挛和昏睡等脑部症状,甚至会死亡。东京大学和富山大学的研究小组发现,如果在短时间内给重症患者大量注射类固醇,可能会取得较好效果。这一成果论文已经刊登在最新一期美国《神经病学》(Neurology)杂志网络版上。 2011 年,日本烤肉连锁店“惠比寿烤肉酒家”的生拌牛肉引发集体食物中毒事件,导致5人死亡,食物中毒是由大肠杆菌 O111 引发的。研

肠出血性大肠杆菌导致食物中毒时,重症患者有时会出现痉挛和昏睡等脑部症状,甚至会死亡。东京大学和富山大学的研究小组发现,如果在短时间内给重症患者大量注射类固醇,可能会取得较好效果。这一成果论文已经刊登在最新一期美国《神经病学》Neurology杂志网络版上。

2011 年,日本烤肉连锁店“惠比寿烤肉酒家”的生拌牛肉引发集体食物中毒事件,导致5人死亡,食物中毒是由大肠杆菌 O111 引发的。研究小组对富山、石川和福井等地的 86 名患者的治疗记录进行了分析。在这些患者中,有 34 人出现了伴随着肾功能衰竭的溶血尿毒综合征,有 21 人出现了痉挛和昏睡等脑部症状。

在最初进行治疗时,医生采用的是血浆交换等治疗手段,但是在开始注射类固醇之后,就不再出现死亡病例,在接受类固醇治疗的 12 名脑部症状患者中,有 11 人没有出现后遗症而康复。研究小组指出,这参考了治疗流感病毒导致的脑部症状时使用类固醇的做法。

在大肠杆菌 O111 导致的食物中毒中,通常有很多患者会出现脑部症状。研究人员表示,对于食物中毒导致的脑部症状,一直缺乏有效的治疗方法,这个发现有可能促进开发出新的治疗方法。

原文出处:

Jun-ichi Takanashi, Hiromichi Taneichi, Takako Misaki, Yuichiro Yahata, Akihisa Okumura, Yoh-ichi Ishida,Toshio Miyawaki, Nobuhiko Okabe, Tetsutaro Sata, and Masashi Mizuguchi. Clinical and radiologic features of encephalopathy during 2011 E coli O111 outbreak in Japan. Neurology, January 17, 2014

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    2014-12-26 yinhl1978
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    2014-01-22 apoenzyme
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    2014-01-22 mashirong
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    2014-01-22 yhy100201

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