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JCEM:桥本氏甲状腺炎患者的冠心病风险更高

2014-10-11 MedSci MedSci原创

甲状腺功能亢进症等甲状腺疾病与心血管疾病的发病相关联,但很少有研究单独探讨自身免疫性疾病和心血管疾病之间的相关性。最近一项研究这项研究旨在发现桥本甲状腺炎和冠心病(CHD)的潜在关联。结果显示,与一般人群相比,桥本氏甲状腺炎患者罹患冠心病的风险更高。这一研究结果发表在内分泌期刊J Clin Endocrinol Metab 10月份在线发表,就来自台湾的研究者发表。既往研究已证实,亚临床甲状腺功能

甲状腺功能亢进症等甲状腺疾病与心血管疾病的发病相关联,但很少有研究单独探讨自身免疫性疾病和心血管疾病之间的相关性。最近一项研究这项研究旨在发现桥本甲状腺炎和冠心病(CHD)的潜在关联。结果显示,与一般人群相比,桥本氏甲状腺炎患者罹患冠心病的风险更高。这一研究结果发表在内分泌期刊J Clin Endocrinol Metab 10月份在线发表,就来自台湾的研究者发表。

既往研究已证实,亚临床甲状腺功能亢进患者罹患冠心病的风险增加约20%。自身免疫性甲状腺疾病也可以通过慢性炎症引发心血管疾病,但很少有研究关注。

这项研究纳入在2000至2010年间新诊断为桥本氏甲状腺炎的1165例20岁以上的患者,以及4660名未患病者作为对照。两组人群在性别、年龄、基线并发疾病及入组时间等方面均相匹配。


桥本氏甲状腺炎患者较对照组冠心病的累积发生率高2.3%。桥本氏甲状腺炎组发生冠心病的校正风险比为1.44  (95%CI= 1.05 - 1.99),高于既往研究的报道值。如果合并高血压或高血脂后,其风险进一步增加,分别达到2.06倍和1.83倍 (adjusted HR = 2.06, 95% CI = 1.46 - 2.92; and adjusted HR = 1.83, 95% CI = 1.31 - 2.55, respectively). 。

即便在校正合并疾病的影响后,桥本氏甲状腺炎仍然是冠心病的显著危险因素。此外,那些未经甲状腺素治疗或治疗时间小于1年的桥本氏甲状腺炎患者罹患冠心病的风险更高,风险分加别增加1.55倍和2.42倍 (adjusted HR = 1.55 95% CI = 0.98 - 2.46; and adjusted HR = 2.42, 95% CI = 1.43 - 3.97).。

这些研究结果进一步证实,无论基线时是否合并其他疾病,桥本氏甲状腺炎均会增加冠心病风险,在女性及年轻患者中尤甚。此外,采用甲状腺素治疗桥本氏甲状腺炎1年以上可以减少冠心病的发生风险。


原始出处:
Chen WH, Chen YK, Lin CL, Yeh JH, Kao CH.Hashimoto's Thyroiditis, Risk of Coronary Heart Disease, and L-thyroxine Treatment: A Nationwide Cohort Study. J Clin Endocrinol Metab. 2014 Oct 1:jc20142990. 

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    2015-09-08 achengzhao
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    2015-06-05 ljjj1053

    好好学习学习

    0

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    2015-02-08 smallant2015
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