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Lipids Health Dis:北大武阳丰教授等研究称,我国急性冠脉事件患者半年后仅七成用他汀,停药者心血管事件易复发

2017-08-18 朱柳媛 中国循环杂志

北京大学临床研究所、乔治全球健康研究院武阳丰教授等报告,我国出院时处方了他汀类药物(他汀)的急性冠脉综合征(ACS)患者,出院6个月时他汀应用率降至了72%。

北京大学临床研究所、乔治全球健康研究院武阳丰教授等报告,我国出院时处方了他汀类药物(他汀)的急性冠脉综合征(ACS)患者,出院6个月时他汀应用率降至了72%。

研究人员发现,他汀依从性差的人,出院12个月时主要不良心血管事件(包括全因死亡、心肌梗死卒中)发生率为2.7%,明显高于依从性好的人(1.8%)。


依从性差是指:出院时服用他汀但出院6个月时减量用或停用他汀。依从性好是指:出院至6个月内一直足量服用他汀。

在出院7~12个月这6个月随访期间,他汀依从性好的人出现主要不良心血管事件的风险会降低27%。

他汀依从性好对患者心血管事件的预防作用,不受他汀应用的剂量、患者的基线临床特征和其他治疗措施的影响。换句话说,急性冠脉综合征患者出院后只要一直坚持足量服用他汀,都会有获益。

作者强调,“我们的研究显示了降脂治疗依从性在预防主要不良心血管事件中的重要性。”

研究人员对中国急性冠脉综合征临床路径研究(CPACS)-1和CPACS-2两个前瞻性注册登记队列1.2万余人进行了分析,这些急性冠脉综合征患者患者出院6个月内没有出现心梗复发或卒中。
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createdName=方舒, createdTime=Fri Aug 18 13:01:10 CST 2017, time=2017-08-18, status=1, ipAttribution=)]
    2018-05-07 bettycmoon
  2. 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createdName=方舒, createdTime=Fri Aug 18 13:01:10 CST 2017, time=2017-08-18, status=1, ipAttribution=)]
    2017-09-27 shizhenshan
  4. 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createdName=方舒, createdTime=Fri Aug 18 13:01:10 CST 2017, time=2017-08-18, status=1, ipAttribution=)]
  5. 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  6. 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createdName=方舒, createdTime=Fri Aug 18 13:01:10 CST 2017, time=2017-08-18, status=1, ipAttribution=)]
    2017-08-20 yinhl1980
  7. 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  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27675, encryptionId=b8012e675d7, topicName=停药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c6d6379100, createdName=yinhl1980, createdTime=Sun Aug 20 03:42:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621650, encodeId=0ed6162165040, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Sun Aug 20 03:42:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234772, encodeId=747b234e7271, content=学习受益匪浅,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri Aug 18 14:51:43 CST 2017, time=2017-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234766, encodeId=5adc234e668e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KiblTyxD95ExbzUoCVcRuhPibXboL28wicFMTXUhCA0RWCyQZYC5Na3ap7CxjialMkB50VEJ0XToQQTC/0, createdBy=470c1945776, createdName=方舒, createdTime=Fri Aug 18 13:01:10 CST 2017, time=2017-08-18, status=1, ipAttribution=)]
    2017-08-18 清风拂面

    学习受益匪浅,谢谢分享

    0

  9. 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GetPortalCommentsPageByObjectIdResponse(id=234772, encodeId=747b234e7271, content=学习受益匪浅,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri Aug 18 14:51:43 CST 2017, time=2017-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234766, encodeId=5adc234e668e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KiblTyxD95ExbzUoCVcRuhPibXboL28wicFMTXUhCA0RWCyQZYC5Na3ap7CxjialMkB50VEJ0XToQQTC/0, createdBy=470c1945776, createdName=方舒, createdTime=Fri Aug 18 13:01:10 CST 2017, time=2017-08-18, status=1, ipAttribution=)]
    2017-08-18 方舒

    学习

    0

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