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Stroke:短暂性脑缺血发作和脑卒中后痴呆危险因素的研究

2015-11-08 崔倩 译 MedSci原创

很多研究建议中风后评估认知能力,但适用于全谱患者的简短认知测试还缺乏数据。因此,研究人员在一项短暂性脑缺血发作(TIA)和脑卒中以人群为基础的研究中,确定了概率,原因和不可预测性。研究人员前瞻性招募(2002- 2007年)TIA或中风患者进入牛津大学血管研究报告>=1简短认知测试(简易精神状态检查,认知状态的电话采访,蒙特利尔认知评估,简易智力测验分数),在基线和在后续5年进行。在1097

很多研究建议中风后评估认知能力,但适用于全谱患者的简短认知测试还缺乏数据。因此,研究人员在一项短暂性脑缺血发作(TIA)和脑卒中以人群为基础的研究中,确定了概率,原因和不可预测性。

研究人员前瞻性招募(2002- 2007年)TIA或中风患者进入牛津大学血管研究报告>=1简短认知测试(简易精神状态检查,认知状态的电话采访,蒙特利尔认知评估,简易智力测验分数),在基线和在后续5年进行。

在1097连续的评估幸存者中(平均年龄/ SD,74.8/12.1岁;378例TIA),基线,1,6,12,和60个月的可测试的简短认知测试数量分别为835/1097(76%),778/947(82%),756/857(88%),692/792(87%),和472/567(83%)。88%的TIA患者(331/378)在基线时可测试,而主要的卒中患者只有46%(133/290)可测试(P<0.001)。不可测试性还与年龄,病前的依赖性,随访中的死亡续,以及事件前后痴呆相关(所有P<0.01)。不可测试性(以及测试中的问题)通常是由于基线时急性卒中的影响引起的(153/262 [58%]:语言障碍/构音障碍/偏瘫=84[32%],嗜睡=58[22%],急性混乱=11,而感觉障碍引起了后期时间点测试的许多相关问题(5年时24/63[38%])。

相当多的TIA和中风患者通过简短的认知测试不能够进行测试。未来的研究应报告不可测患者的数据和那些痴呆可能性较高的的患者中测试的问题。

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