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SCI REP：糖尿病对系统性红斑狼疮患者终末期肾病风险的影响！

2018-04-16 xing.T MedSci原创

糖尿病SLEESRD
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总之，SLE患者合并随后的DM与发生ERSD的潜在更高风险相关。

系统性红斑狼疮（SLE）患者与胰岛素抵抗有关，并患糖尿病的风险更高。SLE和DM可分别导致肾功能衰竭。然而，糖尿病是否会增加SLE患者的终末期肾病（ESRD）风险尚不清楚。

近日，Scientific reports杂志上发表了一篇研究文章，该研究旨在评价DM对SLE患者ESRD发生发展的潜在协同作用。研究人员利用台湾国家健康保险研究数据库进行了这项研究。研究人员招募了新诊断DM的SLE患者作为研究队列。并以1:1比例匹配年龄、性别、年龄相似的无DM的SLE患者作为对照队列，在SLE和DM诊断之间，并通过倾向得分匹配的各种合并症患者被招募。

在随访5.01±3.13年后，ESRD的发病率在DM组明显高于非DM组（发生率为2.71；95%可信区间为1.70–4.32）。在控制混杂因素后，DM并不是ESRD的独立危险因素。透析开始后，DM患者的死亡率与无DM患者相似。

总之，SLE患者合并随后的DM与发生ERSD的潜在更高风险相关。

原始出处：

Ming-Yan Jiang,et al. Impact of Diabetes Mellitus on the Risk of End-Stage Renal Disease in Patients with Systemic Lupus Erythematosus.Scientific reports.2018. https://www.nature.com/articles/s41598-018-24529-2

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    2019-02-20 anminleiryan

    #终末期#

    0

  2. 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    2018-09-26 qingrejiedu

    #系统性#

    0

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    2018-04-22 易水河

    知之为知之学习学习

    0

  4. 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    2018-04-19 yfjms

    学习

    0

  5. 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likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Wed Apr 18 06:58:04 CST 2018, time=2018-04-18, status=1, ipAttribution=)]
    2018-04-18 惠映实验室

    学习了.谢谢分享.

    0

  6. 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    2018-04-18 zengjiayao

    #终末期肾病#

    0

  7. 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    2018-04-18 zhouqu_8

    #红斑#

    0

  8. 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style='color:#2F92EE;'>#狼疮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68144, encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Wed Apr 18 12:09:00 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=306879, encodeId=c20e3068e9a2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Wed Apr 18 07:26:00 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=306847, encodeId=88d030684e3e, content=学习了很多先进的医学知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Wed Apr 18 06:58:04 CST 2018, time=2018-04-18, status=1, ipAttribution=)]
    2018-04-18 sunrural_42825357

    #狼疮#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1693467, encodeId=ba08169346e32, content=<a href='/topic/show?id=7e2de81588c' target=_blank style='color:#2F92EE;'>#终末期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78158, encryptionId=7e2de81588c, topicName=终末期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f6429431807, createdName=anminleiryan, createdTime=Wed Feb 20 07:09:00 CST 2019, time=2019-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2017029, encodeId=ac62201e0294e, content=<a href='/topic/show?id=9760e69058c' target=_blank style='color:#2F92EE;'>#系统性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76905, encryptionId=9760e69058c, topicName=系统性)], attachment=null, authenticateStatus=null, createdAvatar=, 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    2018-04-18 yfjms

    学习

    0

  10. 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likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Wed Apr 18 06:58:04 CST 2018, time=2018-04-18, status=1, ipAttribution=)]
    2018-04-18 雅文博武

    学习了很多先进的医学知识

    0

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Circulation：对于糖尿病患者和无糖尿病的高心血管风险的患者，他汀类药物中添加依泽替米贝可增强治疗效果

当Ezetimibe(依泽替米贝）加入辛伐他汀（Simvastatin）时，可减少急性冠脉综合征后的心血管事件。现有研究人员对以糖尿病（DM）将患者进行分层对预后结果的影响进行探究。IMPROVE-IT试验，共收纳18144位急性冠脉综合征病史的、低密度脂蛋白胆固醇50-125mg/dL的患者，随机分至依泽替米贝/辛伐他汀（E/S）组或安慰剂/辛伐他汀组，均为40mg。主要结点：心源性死亡、冠状动

Mayo Clin Proc：β受体阻滞剂增加冠心病糖尿病患者死亡风险

一项日本研究表明，β受体阻滞剂或会增加糖尿病患者死亡风险，尤其是有冠心病的糖尿病患者。

PLOS ONE：多喝牛奶缓解糖尿病症状

世界各地越来越多的糖尿病患者正在成为对人类健康的严重威胁。已有的研究显示了乳制品对糖尿病具有潜在的有益效果。

以糖尿病为切入点 400位医院管理者共话县域慢病管理

北京时间，2018年4月15日，受国家卫生健康委医政医管局委托，北京协和公共卫生学院联合中国老年保健协会共同开展的“糖尿病预防与控制相关卫生政策研究与县域内分泌学科发展助力工程试点项目”（简称“蓝色县域”）2018启动会在北京隆重举行。来自卫健委、北京协和公共卫生学院以及中国老年保健协会的相关领导、专家学者以及项目试点县域医院的院长、科室管理者等共计400余人齐聚一堂，深入探讨县域慢病管理的话题

Nature Genetics ：这个基因突变会导致女性肥胖！增加糖尿病风险！

随着生活水平的不断提升，Ⅱ型糖尿病的发病率也随之与日俱增。关于其发病原因一直众说纷纭，近日，研究人员发现了糖尿病的一种致病基因KLF14，或许可以解答人们一直以来对于糖尿病病因的众多疑团。

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