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Heart:喝茶的好处又添一笔 能降低缺血性心脏病风险!

2017-06-14 选题审校:安雅晶 编辑:吴刚 环球医学

茶是世界上摄入最广的饮料之一,尤其在中国。2017年5月,发表在《Heart》的一项由中国和英国科学家进行的研究考察了茶摄入与缺血性心脏病(IHD)风险的相关性。

茶是世界上摄入最广的饮料之一,尤其在中国。2017年5月,发表在《Heart》的一项由中国和英国科学家进行的研究考察了茶摄入与缺血性心脏病(IHD)风险的相关性。

目的:旨在前瞻性考察茶摄入与IHD风险之间的关系。

方法:使用中国慢性病前瞻性研究;来自于中国10个地区的参与者于2004~2008年入组,并随访到2013年12月31日。排除了基线癌症患者、心脏病患者和卒中患者后,本研究纳入了基线的199293名男性和288082名女性,这些参与者的年龄均为30~79岁。研究人员通过疾病注册和新的全民健康保险资料库,收集了IHD发生率的数据。

结果:中位7.2年的随访期,研究人员记录到24665例IHD发病病例(71.9例/1000人-年)和3959例严重冠脉事件(MCE)(1.13例/1000人-年)。茶摄入与IHD和MCE风险的降低相关。整个队列中,与过去12个月从未摄入茶的参与者相比,少于每天摄入茶者和每天摄入茶者,其IHD的多变量调整HR及其95% CI为0.97(0.84~1.00)和0.92(0.88~0.95),MCE的多变量调整HR及其95% CI为0.92(0.85~1.00)和0.90(0.82~0.99)。每天摄入者中,茶摄入量之间的IHD和MCE的HR中,未观察到线性趋势(P>0.05)。农村(IHD:P=0.006;MCE:P<0.001)、非肥胖(MCE:P=0.012)和非糖尿病参与者(IHD:P=0.004)中,茶摄入和IHD之间的负相关性较强烈。

结论:在该大型前瞻性研究中,每天茶摄入与IHD风险降低相关。

多学科讨论记实:

既往前瞻性队列研究观察到茶在缺血性心脏病(IHD)预防中的作用的不一致结果。此外,荷兰和日本的证据表明,每日饮茶者中,相关性可能是剂量-效应关系。但是,这些研究大多样本量小,且无法获得精确的效应评估,导致茶摄入与IHD之间的关系仍未得到很好的确立。

每日茶摄入与中国饮茶者IHD风险降低相关。有趣的是,每日饮茶者比那些每天喝的更少的人IHD风险低,但茶量增加不能进一步降低风险。

喝摄入对IHD的保护作用在报告茶摄入年数更长、居住在农村地区、BMI<24 kg/m2且基线无糖尿病的参与者中更强。

除了像既往研究一样按杯测量茶摄入,本研究中,研究人员用添加的茶叶的可数测量茶摄入,这可能是茶摄入的更好测量方式,至少部分反映活性成分的摄入量。

本研究为理解茶在心血管健康中的作用以及将茶作为健康饮料提供了令人信服的证据。

需要考虑一些局限性。茶摄入是自我报告,增加了误分类的可能性。茶摄入的问题未直接验证。茶摄入可能与其他饮食习惯和生活方式行为相关。其他未测量或未知因素造成的残余混杂仍有可能。例如,咖啡摄入可能是混杂因素,但未在此人群的基线中收集。但是,当前人群消耗咖啡较少。因此,咖啡摄入不太可能大幅混淆观察到的相关性。此外,沏茶方法的信息不可用,可能影响茶的活性成分的释放。本研究缺少详细的饮食信息,限制了研究人员考察人群特定饮食模式是否更改茶摄入和IHD之间相关性,以及将结果推广至其他人群。可能发生反向因果关系。确诊或亚临床慢性疾病的参与者可能改变饮食习惯。但是,研究人员在分析中排除了有重大疾病的参与者。此外,当研究人员额外校正消化系统疾病或排除最初2年随访中有IHD事件的参与者时,结果未明显变化。

原始出处:
Li, X., et al. (2017). "Tea consumption and risk of ischaemic heart disease." Heart 103(10): 783-789.

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    2017-06-16 zhaojie88
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    2017-06-16 hbwxf
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    2017-06-16 slcumt
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    2017-06-14 131****1460

    学习了,受益匪浅。

    0

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