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Eur Heart J：亚临床心肌损伤与增痴呆风险

2014-04-04 高晓方 译 医学论坛网

心肌损伤痴呆风险
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美国一项研究表明，基线高敏心肌肌钙蛋白T(hs-cTnT)升高与认知测验评分降低以及后期痴呆住院风险升高具有相关性。研究结果提示亚临床心肌梗死与痴呆和认知具有相关性。论文于3月30日在线发表于《欧洲心脏杂志》(Eur Heart J)。此项研究共纳入9472例受试者，并进行了基线时认知横断面分析和前瞻性痴呆随访。利用新型高敏方法测定hs-cTnT，并利用DWRT、DSST和WFT评估认知功能。通过

美国一项研究表明，基线高敏心肌肌钙蛋白T(hs-cTnT)升高与认知测验评分降低以及后期痴呆住院风险升高具有相关性。研究结果提示亚临床心肌梗死与痴呆和认知具有相关性。论文于3月30日在线发表于《欧洲心脏杂志》(Eur Heart J)。

此项研究共纳入9472例受试者，并进行了基线时认知横断面分析和前瞻性痴呆随访。利用新型高敏方法测定hs-cTnT，并利用DWRT、DSST和WFT评估认知功能。通过ICD-9确定痴呆。利用线性回归和Cox模型校正传统心血管危险因素。

结果显示，受试者平均年龄年龄为63岁，hs-cTnT ≥3 ng/L的患者为66%。在横断面分析中，hs-cTnT较高与DSST和WFT评分较低具有相关性，但与DWRT无关。中位随访13年后共出现455例痴呆住院。在前瞻性分析中，hs-cTnT基线浓度较高与痴呆住院和血管性痴呆风险升高具有相关性，但与阿尔茨海默病痴呆无关。

原始出处：


Schneider AL1, Rawlings AM, Sharrett AR, Alonso A, Mosley TH, Hoogeveen RC, Ballantyne CM, Gottesman RF, Selvin E.High-sensitivity cardiac troponin T and cognitive function and dementia risk: the atherosclerosis risk in communities study.Eur Heart J. 2014 Mar 30. 


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    2014-07-20 TZF0804

    #亚临床心肌损伤#

    0

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    2014-04-06 yangcx0915

    #心肌损伤#

    0

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    2014-04-06 pcw106

    #痴呆风险#

    0

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    2014-04-06 zhaojie88

    #ART#

    0

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    2014-04-06 智者为医08

    #损伤#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1797915, encodeId=2c2d1e979153f, content=<a href='/topic/show?id=b8642420e35' target=_blank style='color:#2F92EE;'>#亚临床心肌损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24207, encryptionId=b8642420e35, topicName=亚临床心肌损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0041445, createdName=TZF0804, createdTime=Sun Jul 20 04:48:00 CST 2014, time=2014-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310038, encodeId=12881310038e0, content=<a href='/topic/show?id=ddd95126e4e' target=_blank style='color:#2F92EE;'>#心肌损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51267, encryptionId=ddd95126e4e, topicName=心肌损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Sun Apr 06 07:48:00 CST 2014, time=2014-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316660, encodeId=8b5e1316660ea, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Sun Apr 06 07:48:00 CST 2014, time=2014-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355844, encodeId=cf0b1355844bd, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Apr 06 07:48:00 CST 2014, time=2014-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396819, encodeId=f532139681950, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Apr 06 07:48:00 CST 2014, time=2014-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562223, encodeId=61a115622238d, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sun Apr 06 07:48:00 CST 2014, time=2014-04-06, status=1, ipAttribution=)]
    2014-04-06 爆笑小医

    #HEART#

    0

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