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Hypertension:高血压与卒中风险相关性的强弱因性别而不同!

2019-09-17 MedSci MedSci原创

高血压和缺血性卒中之间的关系是否因性别而异,目前尚所知甚少。研究人员对高血压严重程度及治疗与缺血性卒中风险之间的性别差异进行研究。研究人员开展了一项纵向队列研究,对黑人个体和那些生活在卒中带的人进行采样。2003年-2007年共招募了26461名参与者,所有受试者既往均无卒中病史。主要结点是缺血性卒中事件。55.4%的受试者为女性,40.2%的受试者为黑人。研究期间,共确诊1084例缺血性卒中事件

高血压和缺血性卒中之间的关系是否因性别而异,目前尚所知甚少。研究人员对高血压严重程度及治疗与缺血性卒中风险之间的性别差异进行研究。

研究人员开展了一项纵向队列研究,对黑人个体和那些生活在卒中带的人进行采样。2003年-2007年共招募了26461名参与者,所有受试者既往均无卒中病史。主要结点是缺血性卒中事件。

55.4%的受试者为女性,40.2%的受试者为黑人。研究期间,共确诊1084例缺血性卒中事件。在经年龄、种族、性别等因素校正后模型中,相同层次高血压(参照/收缩压<120 mmHg/120–129 mmHg/130–139 mmHg/>140 mmHg)的女性(危险比 1.25,95% CI 1.16-1.34),发生卒中的风险要高于男性(危险比 1.14,95% CI 1.05-1.23)。与未采用任何药物控制血压相比,每增加一种药物,女性和男性卒中的风险就分别增加23%和21%。

本研究结果提示高血压和缺血性卒中之间的关系与性别有关,未来需要进一步研究这种关联潜在的生物学机制,或可促进性别特异性临床指南的发展。

原始出处:

Tracy E. Madsen, et al.Sex Differences in Hypertension and Stroke Risk in the REGARDS Study.Hypertension. 2019;74:749–755

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authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Wed Sep 18 01:20:35 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026450, encodeId=1091102645094, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Sep 18 00:45:00 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045897, encodeId=67b1104589e89, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Wed Sep 18 00:45:00 CST 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  5. 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  6. 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authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Wed Sep 18 01:20:35 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026450, encodeId=1091102645094, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Sep 18 00:45:00 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045897, encodeId=67b1104589e89, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Wed Sep 18 00:45:00 CST 2019, time=2019-09-18, status=1, ipAttribution=)]
    2019-09-19 12546fb1m09暂无昵称

    厉害了

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1142552913, createdName=12546fb1m09暂无昵称, createdTime=Thu Sep 19 01:19:29 CST 2019, time=2019-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372871, encodeId=5b4c3e287119, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Wed Sep 18 07:09:17 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372866, encodeId=41f43e2866b8, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Wed Sep 18 01:20:35 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026450, encodeId=1091102645094, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Sep 18 00:45:00 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045897, encodeId=67b1104589e89, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Wed Sep 18 00:45:00 CST 2019, time=2019-09-18, status=1, ipAttribution=)]
    2019-09-18 深海的鱼

    学习学习学习

    0

  8. 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authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Wed Sep 18 01:20:35 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026450, encodeId=1091102645094, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Sep 18 00:45:00 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045897, encodeId=67b1104589e89, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Wed Sep 18 00:45:00 CST 2019, time=2019-09-18, status=1, ipAttribution=)]
  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1142552913, createdName=12546fb1m09暂无昵称, createdTime=Thu Sep 19 01:19:29 CST 2019, time=2019-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372871, encodeId=5b4c3e287119, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Wed Sep 18 07:09:17 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372866, encodeId=41f43e2866b8, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Wed Sep 18 01:20:35 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026450, encodeId=1091102645094, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Sep 18 00:45:00 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045897, encodeId=67b1104589e89, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Wed Sep 18 00:45:00 CST 2019, time=2019-09-18, status=1, ipAttribution=)]
    2019-09-18 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1142552913, createdName=12546fb1m09暂无昵称, createdTime=Thu Sep 19 01:19:29 CST 2019, time=2019-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372871, encodeId=5b4c3e287119, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Wed Sep 18 07:09:17 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372866, encodeId=41f43e2866b8, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Wed Sep 18 01:20:35 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026450, encodeId=1091102645094, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Sep 18 00:45:00 CST 2019, time=2019-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045897, encodeId=67b1104589e89, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Wed Sep 18 00:45:00 CST 2019, time=2019-09-18, status=1, ipAttribution=)]
    2019-09-18 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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