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阿尔茨海默症早期诊断重要工具——MBI-C量表

2016-07-26 MedSci MedSci原创

Zahinoor Ismail和同事开发出一张含有38项内容的详细列表,他们指出,这可以帮助医生更好地评估阿尔茨海默症患者的早期临床表现。他们在2016年阿尔茨海默病协会国际会议(AAIC 2016)上提出该结论。在美国,约有540万人患有老年痴呆症,预计这个数字在未来30年内要翻三倍。 轻度认知障碍(MCI),即患者表现出明显的记忆和思维能力的变化,这被认为是阿尔茨海默症的前兆,因为大多数患有轻

在美国约有540万人患有老年痴呆症预计这个数字在未来30年内要翻三倍。轻度认知障碍(MCI),即患者表现出明显的记忆和思维能力的变化,这被认为是阿尔茨海默症的前兆因为大多数患有轻度认知障碍的患者最终发展为阿尔茨海默症。  

Zahinoor Ismail和同事开发出一张含有38项内容的详细列表,他们指出,这可以帮助医生更好地评估阿尔茨海默症患者的早期临床表现。他们在2016年阿尔茨海默病协会国际会议(AAIC 2016)上提出该结论。

然而Ismail博士和同事认为人格和行为的改变可能出现在MCI之前它们或许是阿兹海默症更早的神经退行性变信号。 

研究人员根据NPI-Q问卷(评估痴呆患者出现的性格和行为变化的量表)调查列出详细的MBI-C问卷。

另一项研究中研究人员发现超过80%的MCI或主观认知能力下降(SCD)的患者都表现出可自我感知的记忆和思维能力下降,即神经精神症状(NPS)。具体而言,77.8%的患者出现了情绪的改变64.4%的患者易冲动51.7%的患者冷漠感减少。27.8%的患者出现了社会适应能力改变,8.7%的患者患有精神病。 

研究表明MBI可能是一个常见的和临床相关的综合症NPS表现更为突出,照顾者也面临更大的负担。但是由于NPI-Q问卷为痴呆患者所用因此他们还需要进行更进一步的研究以探究出适合年轻人和非痴呆患者的MBI问卷。根据网上投票结果,研究人员制定出一份含有38项内容的问卷调查,以评估阿尔茨海默症患者早期的神经精神症状:

冷漠/逼迫感/动机 
情绪影响/焦虑 
冲动控制能力/反馈调节 
适应社会能力 
想法/观念的转变 

但研究人员强调MBI-C需要进行更多测试以评估它的有效性和可行性。一旦可行,它将是一个诊断阿尔茨海默症早期表现的十分重要的工具,帮助医生尽早确立有效诊断。

原始出处:

Personality behavioral changes may signal Alzheimer's. MNT.2016 July 26.

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    2017-06-24 Julie W

    研究人员强调,MBI-C需要进行更多测试,以评估它的有效性和可行性。一旦可行,它将是一个诊断阿尔茨海默症早期表现的十分重要的工具,帮助医生尽早确立有效诊断。

    0

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  5. 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    2016-10-11 ylzr123

    赞了,认真探究、学习。

    0

  6. 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    2016-09-10 巴黎夜雨

    嗯,好东西,

    0

  7. 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createdTime=Tue Oct 11 20:14:46 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=121401, encodeId=a5301214014b, content=嗯,好东西,, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A3418665C867262.jpg, createdBy=16b41925372, createdName=巴黎夜雨, createdTime=Sat Sep 10 21:09:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=116844, encodeId=d1fc1168448f, content=赞!好文章,拜读,深入学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 09 19:50:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382642, encodeId=e6ef138264228, content=<a href='/topic/show?id=1f4e5946422' target=_blank style='color:#2F92EE;'>#早期诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59464, encryptionId=1f4e5946422, topicName=早期诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Jul 28 01:08:00 CST 2016, time=2016-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470079, encodeId=2ca014e00791c, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Thu Jul 28 01:08:00 CST 2016, time=2016-07-28, status=1, ipAttribution=)]
    2016-09-09 1e10c84am36(暂无匿称)

    赞!好文章,拜读,深入学习。

    0

  8. 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  9. 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