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Aging Clin Exp Res:肌肽可作为监测接受康复和营养治疗的髋部骨折患者肌肉减少症发生的生物标志物

2021-04-18 MedSci原创 MedSci原创

髋部骨折是最常见的与老年人残疾有关的骨质疏松性骨折,需要手术和随后的康复治疗。目前,肌肉减少症被认为是髋部骨折患者结局恶化的预测因素,最近有学者提出肌肽可作为潜在的生物标志物,为此研究人员进行了探究,

髋部骨折是最常见的与老年人残疾有关的骨质疏松性骨折,需要手术和随后的康复治疗。目前,肌肉减少症被认为是髋部骨折患者结局恶化的预测因素,最近有学者提出肌肽可作为潜在的生物标志物,为此研究人员进行了探究,结果已发表于Aging Clin Exp Res。

研究人员将20例全髋关节置换术后的髋部骨折患者(平均年龄75.9±2.4岁)随机分为两组,每组10名受试者(A组和B组)。两组均执行康复计划(2周5次,每次40分钟/周,然后进行家庭锻炼方案)。此外,A组还接受了2个月的氨基酸补充。

 

结果显示,干预2个月后,A组和B组的血清肌肽水平均显著下降(P = 0.01),组间无统计学意义上的差异。有趣的是,在A组的肌肉减少症患者中观察到血清肌肽水平显著降低(1.3±0.3 vs 0.9±0.5 ng/mL;p = 0.04),但在B组的患者中没有观察到(1.2±0.6 vs 1.0±0.7 ng/mL;p = 0.12)。

综上所述,这些结果表明,肌肽或是髋部骨折老年患者进行康复和氨基酸补充的一个好的生物标志物,可用于检测骨质疏松症。

 

原始出处:

 

Alessandro de Sire, et al., Myostatin as a potential biomarker to monitor sarcopenia in hip fracture patients undergoing a multidisciplinary rehabilitation and nutritional treatment: a preliminary study. Aging Clin Exp Res. 2020 May;32(5):959-962. doi: 10.1007/s40520-019-01436-8.  

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    2022-07-23 小小医者

    #髋部骨折#是相对严重的!尤其是老人

    0

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    2021-04-20 liuquan
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    2021-04-19 ms3000000293407257

    学习

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