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Neurology:老年颈动脉夹层患者更易误诊

2017-03-20 MedSci MedSci原创

目的:在一组诊断为颈动脉夹层的患者(CeAD),确定年龄≥60岁患者的比例,并且比较年龄≥60岁及<60岁患者的特征的频率特性(症状、危险因素和预后)。方法:研究者结合确诊为CeAD的三大队列研究中患者的数据(即颈动脉夹层与缺血性卒中患者联盟)。研究者将病例分为年龄≥60岁和<60岁这两组,并比较两组间临床特点、危险因素、血管特征及3个月预后。首先,研究者对汇集个别病人的数据进行汇总分析。在每个队

目的:在一组诊断为颈动脉夹层的患者(CeAD),确定年龄≥60岁患者的比例,并且比较年龄≥60岁及<60岁患者的特征的频率特性(症状、危险因素和预后)。

方法:研究者结合确诊为CeAD的三大队列研究中患者的数据(即颈动脉夹层与缺血性卒中患者联盟)。研究者将病例分为年龄≥60岁和<60岁这两组,并比较两组间临床特点、危险因素、血管特征及3个月预后。首先,研究者对汇集个别病人的数据进行汇总分析。在每个队列和跨队列进行二次分析。计算粗和校正比值比OR (95%CI)。

结果:确诊的CeAD的患者共2391例,年龄超过≥60岁的患者177例(7.4%)。在这个年龄组,颈部疼痛(校正OR 0.47 [ 0.33-0.66 ])、头痛(校正 OR 0.58 [ 0.42-0.79 ]),机械性触发事件(校正OR 0.53 [ 0.36-0.77 ])和偏头痛(校正OR 0.58 [ 0.39-0.85 ])的发生率比年轻患者频繁。反过来,老年患者高胆固醇血症(校正OR1.52 [ 1.1-2.10 ])和高血压(校正OR 3.08 [ 2.25-4.22 ])更为常见。二级分析中证实年龄组间的主要差异。在多变量分析中,校正分析,老年组患者良好预后(校正OR 0.45 [ 0.25,0.83 ])(即,改良Rankin量表评分0-2)较少见。

结论:在确诊为CeAD的患者中,年龄≥60岁的比例为1/14。在这些患者中,疼痛和机械触发可能较少,使诊断更具挑战性,增加了老年患者漏诊CeAD的风险。


原文出处:

Traenka C, Dougoud D, et al. Cervical artery dissection in patients ≥60 years: Often painless, few mechanical triggers. Neurology. 2017 Mar 3.

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