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2016 脑损伤神经功能损害与修复专家共识

2016-04-30 中国神经科学学会 中华神经创伤外科电子杂志.2016,2(2):100-104.

颅脑损伤常见原因有交通事故、坠落、暴力伤害和突发自然灾害等。在中国每年有超过130 万人因交通事故导致意外伤害。颅脑创伤占全部创伤的17%~23%,重型颅脑损伤的死亡率大于20%,严重残废率大于50%。对于长期昏迷、瘫痪、认知障碍等严重神经功能损害的患者,传统的治疗效果有限。从神经损伤修复学的角度研究神经组织对创伤的反应、神经功能损害与修复治疗的新技术及新方法是神经科学发展的重要方向。目前中国

中文标题:

2016 脑损伤神经功能损害与修复专家共识

发布机构:

中国神经科学学会

发布日期:

2016-04-30

简要介绍:

颅脑损伤常见原因有交通事故、坠落、暴力伤害和突发自然灾害等。在中国每年有超过130 万人因交通事故导致意外伤害。颅脑创伤占全部创伤的17%~23%,重型颅脑损伤的死亡率大于20%,严重残废率大于50%。对于长期昏迷、瘫痪、认知障碍等严重神经功能损害的患者,传统的治疗效果有限。从神经损伤修复学的角度研究神经组织对创伤的反应、神经功能损害与修复治疗的新技术及新方法是神经科学发展的重要方向。目前中国尚无神经损伤修复相关的标准或指南,特制定本专家共识以供参考。

脑损伤神经功能损害的临床表现

脑损伤后神经功能损害包括昏迷、认知障碍、运动及感觉功能损害、语言功能障碍和视力损害等。

1. 昏迷:亦称意识障碍,是指患者失去意识,对外界刺激没有任何反应。依据昏迷的程度分为深度、中度和浅度昏迷。 

当重型颅脑损伤有下列情况时可能发生昏迷:

(1)有广泛的脑挫裂伤伴急性脑肿胀或弥散性脑水肿伴脑疝形成;

(2)急性颅内血肿继发脑疝;

(3)弥漫性轴损伤;

(4)严重脑干损伤等。 

如昏迷超过 3 个月以上者称为迁延性昏迷, 或称植物生存状态(植物人),患者表现为有觉醒周期,但是与外界没有主动反应和交流。 

2. 认知障碍:在额颞叶损伤者较为多见。 轻伤患 者 伤 后 3 个月 内 记 忆 和 注 意 障 碍 的 发 生 率 为40%~60%,中、重型脑损伤患者可高达 90%。 临床主要表现为注意力不能持续集中,难以完成交谈、阅读、看电视及进行一连串的思考;记忆力不同程度减退;学习兴趣和语言表达能力下降;分析判断能力减退,工作能力下降。 

3. 运动及感觉障碍: 若损伤 累及内囊基 底节区,破坏皮质脊髓束、皮质脑干束以及上行的感觉传导纤维,患者表现为对侧肢体运动及感觉功能损害、中枢性面瘫等。 

4. 语言功能障碍:优势半球额颞叶广泛挫裂伤可导致语言中枢受损。语言运动中枢,又叫言语运动中枢,位于大脑优势半球额下回后部(4445 ),称作 Broca 区。 该区受损时患者能理解对方语言意思,但是不能做出正确语言表达,称为运动性失语。听觉性语言中枢位于颞上回后部(22 ),此中枢的功能是调整自身的语言和听取、理解别人的语言,该中枢受损表现为感觉性失语症。 

5. 视力损害:创伤累及视神经、视交叉、视 束、视放射或视皮质时,可发生视力及视野的损害,可表现为一侧偏盲、双颞侧偏盲等。

制定者:

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[AttachmentFileName(sort=100, fileName=2016 脑损伤神经功能损害与修复专家共识)] GetToolGuiderByIdResponse(projectId=1, id=efc141c00129a548, title=2016 脑损伤神经功能损害与修复专家共识, enTitle=, guiderFrom=中华神经创伤外科电子杂志.2016,2(2):100-104., authorId=null, author=, summary=颅脑损伤常见原因有交通事故、坠落、暴力伤害和突发自然灾害等。在中国每年有超过130 万人因交通事故导致意外伤害。颅脑创伤占全部创伤的17%~23%,重型颅脑损伤的死亡率大于20%,严重残废率大于50%。对于长期昏迷、瘫痪、认知障碍等严重神经功能损害的患者,传统的治疗效果有限。从神经损伤修复学的角度研究神经组织对创伤的反应、神经功能损害与修复治疗的新技术及新方法是神经科学发展的重要方向。目前中国, cover=, journalId=null, articlesId=null, associationId=1301, associationName=中国神经科学学会, associationIntro=, copyright=0, guiderPublishedTime=Sat Apr 30 00:00:00 CST 2016, originalUrl=, linkOutUrl=, content=<div> <div>颅脑损伤常见原因有交通事故、坠落、暴力伤害和突发自然灾害等。在中国每年有超过130 万人因交通事故导致意外伤害。颅脑创伤占全部创伤的17%~23%,重型颅脑损伤的死亡率大于20%,严重残废率大于50%。对于长期昏迷、瘫痪、认知障碍等严重神经功能损害的患者,传统的治疗效果有限。从神经损伤修复学的角度研究神经组织对创伤的反应、神经功能损害与修复治疗的新技术及新方法是神经科学发展的重要方向。目前中国尚无神经损伤修复相关的标准或指南,特制定本专家共识以供参考。</div><div><p class="MsoNormal" style="margin-top:6.0pt"><span style="font-weight: bold; color: rgb(51, 102, 255);">脑损伤神经功能损害的临床表现</span></p><p class="MsoNormal" style="margin-top:6.0pt">脑损伤后神经功能损害包括昏迷、认知障碍、运动及感觉功能损害、语言功能障碍和视力损害等。</p> <p class="MsoNormal" style="margin-top:6.0pt"><span style="font-weight: bold;"><span lang="EN-US">1. </span>昏迷:</span>亦称意识障碍,是指患者失去意识,对外界刺激没有任何反应。依据昏迷的程度分为深度、中度和浅度昏迷。 </p><p class="MsoNormal" style="margin-top:6.0pt">当重型颅脑损伤有下列情况时可能发生昏迷:</p><p class="MsoNormal" style="margin-top:6.0pt"><span lang="EN-US">(1)</span>有广泛的脑挫裂伤伴急性脑肿胀或弥散性脑水肿伴脑疝形成;</p><p class="MsoNormal" style="margin-top:6.0pt"><span lang="EN-US">(2)</span>急性颅内血肿继发脑疝;</p><p class="MsoNormal" style="margin-top:6.0pt"><span lang="EN-US">(3)</span>弥漫性轴损伤;</p><p class="MsoNormal" style="margin-top:6.0pt"><span lang="EN-US">(4)</span>严重脑干损伤等。 </p><p class="MsoNormal" style="margin-top:6.0pt">如昏迷超过<span lang="EN-US"> 3 </span>个月以上者称为迁延性昏迷, 或称植物生存状态<span lang="EN-US">(</span>植物人<span lang="EN-US">)</span>,患者表现为有觉醒周期,但是与外界没有主动反应和交流。<span style="font-size: 9pt;"> </span></p> <p class="MsoNormal" style="margin-top:6.0pt"><span style="font-weight: bold;"><span lang="EN-US">2. </span>认知障碍:</span>在额颞叶损伤者较为多见。 轻伤患 者 伤 后<span lang="EN-US"> 3 </span>个月 内 记 忆 和 注 意 障 碍 的 发 生 率 为<span lang="EN-US">40%~60%</span>,中、重型脑损伤患者可高达<span lang="EN-US"> 90%</span>。 临床主要表现为注意力不能持续集中,难以完成交谈、阅读、看电视及进行一连串的思考;记忆力不同程度减退;学习兴趣和语言表达能力下降;分析判断能力减退,工作能力下降。<span style="font-size: 9pt;"> </span></p> <p class="MsoNormal" style="margin-top:6.0pt"><span style="font-weight: bold;"><span lang="EN-US">3. </span>运动及感觉障碍:</span> 若损伤 累及内囊基 底节区,破坏皮质脊髓束、皮质脑干束以及上行的感觉传导纤维,患者表现为对侧肢体运动及感觉功能损害、中枢性面瘫等。<span style="font-size: 9pt;"> </span></p> <p class="MsoNormal" style="margin-top:6.0pt"><span style="font-weight: bold;"><span lang="EN-US">4. </span>语言功能障碍:</span>优势半球额颞叶广泛挫裂伤可导致语言中枢受损。语言运动中枢,又叫言语运动中枢,位于大脑优势半球额下回后部<span lang="EN-US">(44</span>、<span lang="EN-US">45 </span>区<span lang="EN-US">)</span>,称作<span lang="EN-US"> Broca </span>区。 该区受损时患者能理解对方语言意思,但是不能做出正确语言表达,称为运动性失语。听觉性语言中枢位于颞上回后部<span lang="EN-US">(22 </span>区<span lang="EN-US">)</span>,此中枢的功能是调整自身的语言和听取、理解别人的语言,该中枢受损表现为感觉性失语症。<span style="font-size: 9pt;"> </span></p> <p class="MsoNormal" style="margin-top:6.0pt"><span style="font-weight: bold;"><span lang="EN-US">5. </span>视力损害:</span>创伤累及视神经、视交叉、视 束、视放射或视皮质时,可发生视力及视野的损害,可表现为一侧偏盲、双颞侧偏盲等。</p> <span style="font-weight: bold;">制定者:</span> <div>中国神经科学学会(CNS,Chinese Neuroscience Society) <div>神经损伤与修复分会<br> </div><div><br></div> 拓展指南:<strong>与<font color="red">脑损伤</font>相关指南:</strong><br><ul><li><a href="//www.sandwebs.com/guideline/show_article.do?id=efc141c00129a548" title="2016 脑损伤神经功能损害与修复专家共识" target="_blank">2016 脑损伤神经功能损害与修复专家共识</a></li> <li><a href="//www.sandwebs.com/guideline/show_article.do?id=281d31c00128866a" title="2016 严重创伤性颅脑损伤的管理指南(第4版)[全文]" target="_blank">2016 严重创伤性颅脑损伤的管理指南(第4版)[全文]</a></li> <li><a href="//www.sandwebs.com/guideline/show_article.do?id=b44a31c001288534" title="2016 严重创伤性颅脑损伤的管理指南(第4版)" target="_blank">2016 严重创伤性颅脑损伤的管理指南(第4版)</a></li> <li><a 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    2021-09-26 14685ec5m56暂无昵称

    求分享

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1054976, encodeId=df0910549e652, content=求分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:30:52 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054975, encodeId=5d7910549e54d, content=为啥没有一个专门运动障碍的, beContent=null, objectType=guider, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:30:48 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054974, encodeId=6e0310549e4c1, content=求分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:30:32 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054966, encodeId=e9401054966e4, content=分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:26:00 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151129, encodeId=f02d151129d8, content=感谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ymfL5Zp0DAJIHrmbxRvg2nT1afxJ2zTz2n1jxnzgTM433XvTFaHiaIkG6icvAQG7dweOYp61AbhCcA/0, createdBy=f9a61970986, createdName=蘑菇鸡蛋, createdTime=Tue Oct 25 14:46:11 CST 2016, time=2016-10-25, status=1, ipAttribution=)]
    2021-09-26 14685ec5m56暂无昵称

    为啥没有一个专门运动障碍的

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1054976, encodeId=df0910549e652, content=求分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:30:52 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054975, encodeId=5d7910549e54d, content=为啥没有一个专门运动障碍的, beContent=null, objectType=guider, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:30:48 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054974, encodeId=6e0310549e4c1, content=求分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:30:32 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054966, encodeId=e9401054966e4, content=分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:26:00 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151129, encodeId=f02d151129d8, content=感谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ymfL5Zp0DAJIHrmbxRvg2nT1afxJ2zTz2n1jxnzgTM433XvTFaHiaIkG6icvAQG7dweOYp61AbhCcA/0, createdBy=f9a61970986, createdName=蘑菇鸡蛋, createdTime=Tue Oct 25 14:46:11 CST 2016, time=2016-10-25, status=1, ipAttribution=)]
    2021-09-26 14685ec5m56暂无昵称

    求分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1054976, encodeId=df0910549e652, content=求分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:30:52 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054975, encodeId=5d7910549e54d, content=为啥没有一个专门运动障碍的, beContent=null, objectType=guider, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:30:48 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054974, encodeId=6e0310549e4c1, content=求分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:30:32 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054966, encodeId=e9401054966e4, content=分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:26:00 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151129, encodeId=f02d151129d8, content=感谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ymfL5Zp0DAJIHrmbxRvg2nT1afxJ2zTz2n1jxnzgTM433XvTFaHiaIkG6icvAQG7dweOYp61AbhCcA/0, createdBy=f9a61970986, createdName=蘑菇鸡蛋, createdTime=Tue Oct 25 14:46:11 CST 2016, time=2016-10-25, status=1, ipAttribution=)]
    2021-09-26 14685ec5m56暂无昵称

    分享

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1054976, encodeId=df0910549e652, content=求分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:30:52 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054975, encodeId=5d7910549e54d, content=为啥没有一个专门运动障碍的, beContent=null, objectType=guider, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:30:48 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054974, encodeId=6e0310549e4c1, content=求分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:30:32 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054966, encodeId=e9401054966e4, content=分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aeb85145483, createdName=14685ec5m56暂无昵称, createdTime=Sun Sep 26 14:26:00 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=151129, encodeId=f02d151129d8, content=感谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ymfL5Zp0DAJIHrmbxRvg2nT1afxJ2zTz2n1jxnzgTM433XvTFaHiaIkG6icvAQG7dweOYp61AbhCcA/0, createdBy=f9a61970986, createdName=蘑菇鸡蛋, createdTime=Tue Oct 25 14:46:11 CST 2016, time=2016-10-25, status=1, ipAttribution=)]
    2016-10-25 蘑菇鸡蛋

    感谢分享

    0

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