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Crit Care:非ST段抬高型心肌梗死患者闭塞的犯罪动脉患病率和结局分析!

2018-02-09 xing.T MedSci原创

由此可见,大部分是NSTEMI人群为OCA患者。这些患者表现出更严重的症状和更差的临床结局。这些患者是否应该采取更积极的治疗策略还有待进一步研究。

近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,研究人员旨在明确非ST段抬高心肌梗死(NSTEMI)患者闭塞的犯罪动脉(OCA)患病率和影响。

研究人员检索了PubMed、EMBASE和Web of Science等数据库,不受任何语言限制,检索时间截止至2016年7月1日。NSTEMI成人的观察性队列或临床试验具有资格入组,以确定OCA在冠状动脉造影术中的比例。如果报告了OCA与临床终点之间的关联的研究,则进一步纳入分析以确定对结局的影响。

在纳入的25项NSTEMI患者的研究中,有8812例患者发生OCA。NSTEMI患者中OCA的平均比例为34%(95%可信区间为30-37%)。OCA患者更可能以左旋动脉为犯罪动脉(比值比(OR)为1.65,95%可信区间为1.15-2.37,P=0.007),与非闭塞性犯罪动脉相比,左旋动脉作为犯罪动脉与较低的左心室射血分数(标准差为-0.29,95%可信区间为-0.34至-0.34,P<0.001)、较高的酶峰值水平(标准差为0.43,95%可信区间为0.27-0.58,P<0.001)和较高的心源性休克风险(OR为1.66,95%可信区间为1.35-2.04,P<0.001)相关。OCA患者的死亡率(OR为1.72,95%可信区间为1.49-1.98,P<0.001)和复发性心肌梗死(OR为1.7,95%可信区间为1.06-2.75,P=0.029)也高于非闭塞性犯罪动脉患者。

由此可见,大部分是NSTEMI人群为OCA患者。这些患者表现出更严重的症状和更差的临床结局。这些患者是否应该采取更积极的治疗策略还有待进一步研究。

原始出处:

Chi-Sheng Hung,et al. Prevalence and outcome of patients with non-ST segment elevation myocardial infarction with occluded “culprit” artery–a systemic review and meta-analysis.Critical Care.2018. https://doi.org/10.1186/s13054-018-1944-x

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  6. 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content=v还好还好很久很久, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sat Feb 10 11:06:59 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286717, encodeId=67ff286e1732, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sat Feb 10 07:46:52 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286552, encodeId=62da28655226, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Fri Feb 09 14:23:05 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-02-11 gdsun
  7. 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objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Fri Feb 09 14:23:05 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-02-11 hyf035
  8. 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    2018-02-10 为你把脉

    v还好还好很久很久

    0

  9. 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content=v还好还好很久很久, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sat Feb 10 11:06:59 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286717, encodeId=67ff286e1732, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sat Feb 10 07:46:52 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286552, encodeId=62da28655226, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Fri Feb 09 14:23:05 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-02-10 wzb521zf

    一起学习学习

    0

  10. 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content=v还好还好很久很久, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sat Feb 10 11:06:59 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286717, encodeId=67ff286e1732, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sat Feb 10 07:46:52 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286552, encodeId=62da28655226, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Fri Feb 09 14:23:05 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-02-09 131****1460

    学习了受益匪浅

    0

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阜外医院杨跃进教授牵头的中国急性心肌梗死注册(CAMI)研究近期报告,在中国非ST段抬高型心肌梗死(NSTEMI)患者在住院期间有6%的患者死亡,有12个因素是患者死亡的高危因素。

降糖药物“变天”:心血管科医生为降糖新药感到振奋

正常生理情况下,肾脏每天经过肾小球滤过约160~180克葡萄糖到肾小管中,但滤过的葡萄糖有可通过钠一葡萄糖共转运蛋白(SGLT)重吸收到血液循环中。一般情况下,当血糖浓度超过10mmol/L时葡萄糖会漏出到尿液中。而使用SGLT2抑制剂,就能抑制葡萄糖重吸收,促进尿葡萄糖排泄,从而达到降低血液循环中葡萄糖水平的作用。

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