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Am J Cardiol:脂蛋白亚组分评估有助预测冠脉钙化

2012-11-16 高晓方译 医学论坛网

  美国学者的一项研究表明,在心血管中等风险的患者中,脂蛋白亚组分评估可为预测冠脉钙化提供传统危险因素之外的附加信息。论文于2012年11月7日在线发表于《美国心脏病学杂志》(Am J Cardiol)。   此项研究共序贯性纳入410心血管中等风险患者。受试者平均年龄57岁,女性占29%,并且均接受冠脉钙化(钙化评分)CT评估。利用经验证的超速离心法对洗脱脂蛋白亚组分(低、

  美国学者的一项研究表明,在心血管中等风险的患者中,脂蛋白亚组分评估可为预测冠脉钙化提供传统危险因素之外的附加信息。论文于2012年11月7日在线发表于《美国心脏病学杂志》(Am J Cardiol)。

  此项研究共序贯性纳入410心血管中等风险患者。受试者平均年龄57岁,女性占29%,并且均接受冠脉钙化(钙化评分)CT评估。利用经验证的超速离心法对洗脱脂蛋白亚组分(低、极低、中、高密度脂蛋白亚型,脂蛋白以及优势LDL分布)进行直接定量。

  结果显示,共有297例(72.4%)患者伴有冠脉钙化。对传统危险因素进行校正后,B型LDL(低密度颗粒占优势)为冠脉钙化的独立预测因素[比值比(OR)4.46]。但对血脂异常进行附加分层之后,在血脂正常组中仅高密度脂蛋白亚组分2(OR 3.45)和“真正”LDL(OR 6.10)具有显著预测价值,在血脂异常组中仅脂蛋白(a)具有显著预测价值(OR 7.81)。

 

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