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匹兹堡大学卢斌峰教授:肿瘤进展对组织免疫炎症反应的调节

2016-09-02 佚名 生物谷

9月2日"2016癌症、炎症与免疫--微环境下的对话"会议,此次会议由生物谷主办,邀请了相关领域内来自海内外各个院校、研究机构的优秀专家学者,就:癌症与炎症性免疫、非可控性炎症与癌症、临床医学转化等方面的议题作了精彩演讲。 各位专家分别从自身研究的角度解读了癌症、炎症、免疫这三者之间的关联,探讨了非可控性炎症癌症转化的关系以及治疗策略,为肿瘤治疗与临床转化指出了新的方向。 大会首日,来

9月2日"2016癌症、炎症与免疫--微环境下的对话"会议,此次会议由生物谷主办,邀请了相关领域内来自海内外各个院校、研究机构的优秀专家学者,就:癌症与炎症性免疫、非可控性炎症与癌症、临床医学转化等方面的议题作了精彩演讲。

各位专家分别从自身研究的角度解读了癌症、炎症、免疫这三者之间的关联,探讨了非可控性炎症癌症转化的关系以及治疗策略,为肿瘤治疗与临床转化指出了新的方向。

大会首日,来自美国匹兹堡大学的卢斌峰教授做了题为"肿瘤进展对组织免疫炎症反应的调节"的演讲,引起了各位嘉宾和到会人士的关注。肿瘤发生和发展与免疫炎症反应有着紧密联系和互动。大量的基础和临床研究证明,肿瘤的进展伴随着组织局部免疫反应的降低和抑制。这种肿瘤微环境的变化是很多肿瘤免疫治疗失败的主要原因。卢教授在演讲中提出一个思路,可以根据免疫基因的表达情况来对患者进行分类。卢教授的实验室在研究中发现一系列与免疫启动密切相关的危险信号分子,包括IL-33和IL-36,在肿瘤生成的过程中受到了抑制。在肿瘤细胞中大量表达这些因子可以显着抑制肿瘤的生长和扩散。同时,已经证明这种对于肿瘤的抑制源于这些因子高效提高了机体对肿瘤的免疫攻击。这些研究提出了肿瘤免疫新的作用机制,并且为肿瘤免疫治疗提供了新的思路。

会后,卢教授接受了生物谷的独家采访,长年从事免疫学研究的学术背景使他对于肿瘤发展过程中免疫反应的变化有着浓厚的兴趣。卢教授表示,对于免疫基因表达的研究有着很广阔的应用前景,目前常用的PD1等药物都收获了较为显着的疗效,这从一个方面证明T细胞对于控制肿瘤病人长期生存有着很大的潜力。

对于癌症免疫疗法的发展前景,卢教授也表示十分地看好。他提到,以前在癌症治疗中免疫疗法只是一个辅助手段,但在目前已经成为一个一线的治疗方法。卢教授同时也提到癌症免疫疗法目前面临的一些瓶颈问题,例如毒性问题等。但这些问题都有望在未来的研究和药物研发中得到解决。卢教授认为,癌症免疫疗法仍将是未来癌症治疗领域的一个重要途径。

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    2016-09-05 1e0d99ddm02(暂无匿称)

    卢教授说的很对,增加患者的免疫力确实能提高患者战胜癌症的几率!

    0

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    2016-09-05 1e0d99ddm02(暂无匿称)

    这个研究可以借鉴,学习了!

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1690316, encodeId=27d2169031637, content=<a href='/topic/show?id=3f7933e4253' target=_blank style='color:#2F92EE;'>#匹兹堡大学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33742, encryptionId=3f7933e4253, topicName=匹兹堡大学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30b929034422, createdName=xxxx1059, createdTime=Sun Aug 13 00:39:00 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1737202, encodeId=bab01e37202ad, content=<a href='/topic/show?id=611e8312358' target=_blank style='color:#2F92EE;'>#肿瘤进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83123, encryptionId=611e8312358, topicName=肿瘤进展)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c47234265932, createdName=ms8435843352634314, createdTime=Thu Sep 29 05:39:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2060737, encodeId=89f72060e37c5, content=<a href='/topic/show?id=7f5f2908397' target=_blank style='color:#2F92EE;'>#免疫炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29083, encryptionId=7f5f2908397, topicName=免疫炎症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Wed Oct 05 04:39:00 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=111655, encodeId=69a01116553b, content=卢教授说的很对,增加患者的免疫力确实能提高患者战胜癌症的几率!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Mon Sep 05 17:56:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=111656, encodeId=7132111656e4, content=这个研究可以借鉴,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Mon Sep 05 17:56:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1320826, encodeId=e6981320826e0, content=<a href='/topic/show?id=43de6e0076f' target=_blank style='color:#2F92EE;'>#炎症反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67007, encryptionId=43de6e0076f, topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sun Sep 04 12:39:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110496, encodeId=17b811049695, content=明白了, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Sep 03 20:59:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110389, encodeId=835011038926, content=阅读了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Sep 03 14:50:00 CST 2016, time=2016-09-03, status=1, ipAttribution=)]
    2016-09-03 oo902

    明白了

    0

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    2016-09-03 刘煜

    阅读了。

    0

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