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JAHA:颈动脉粥样硬化可预测高血压患者的血压控制情况

2022-01-20 MedSci原创 MedSci原创

接受降压治疗的高血压患者出现CP与随访期间血压控制不佳相关,但与较差的代谢特征和左心室肥厚无关。

2018年欧洲心脏病学会/欧洲高血压学会-动脉高血压指南不推荐将常规颈动脉超声检查作为识别高血压引起器官损伤的工具,除非患者有临床指征。然而,颈动脉斑块(CP)与动脉僵硬度增加密切相关,随着时间的推移会影响血压(BP)控制。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在评估首次就诊时存在CP的证据是否可以预测随访期间的血压控制情况。

研究人员从CSN登记处确定了6684名高血压患者,他们接受了完整的颈动脉超声检查,并根据受试者基线是否存在CP进行分类。最佳血压控制定义为随访期间诊室和家庭血压的平均血压分别<140/90mmHg和<135/85mmHg。

在基线时,伴有CP的参与者(n=3061)更有可能是男性、年龄较大、更有可能患有糖尿病,并且表现出更高的收缩压、更低的舒张压、更差的血脂参数和更高的左心室肥厚患病率(所有P<0.0001),相比于不伴有CP的患者。54%伴有CP和62%不伴有CP(P<0.0001)的参与者被判定达到了最佳诊室血压控制水平,51%伴有CP和58%不伴有CP(P<0.01)的参与者被判定达到了最佳家庭血压水平。CP的存在与随访期间达到诊室血压控制的可能性降低著着相关(所有P<0.0001),独立于年龄较大、男性、较高的基线血压值、药物类别和左心室伴有肥大的显著效应,并且仅因高血压持续时间而有所减弱。

由此可见,接受降压治疗的高血压患者出现CP与随访期间血压控制不佳相关,但与较差的代谢特征和左心室肥厚无关。

原始出处:

Costantino Mancusi.et al.Carotid Atherosclerosis Predicts Blood Pressure Control in Patients With Hypertension: The Campania Salute Network Registry.JAHA.2022.https://www.ahajournals.org/doi/10.1161/JAHA.121.022345

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    2022-01-21 zhaohui6731
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