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Cerebrovasc Dis:卒中后血糖升高可预测非糖尿病患者不良预后

2015-10-22 phylis 译 MedSci原创

背景:急性缺血性(IS)患者血糖升高时不良预后的标记物。研究者旨在评估HbA1C和第一次测量的血糖水平对3个月死亡率的预测能力。方法:在一项前瞻性分析中,1317名首发IS的患者,按照第一次血糖值分类(低于155,155到199间,大于200mg/dl)。分析非糖尿病的患者,糖尿病但血糖控制(PGC)良好的(HbA1C<7%)患者,糖尿病但血糖控制不好(HbA1C≥7.0%)。结果:3个月死

背景:高血糖症是急性缺血性卒中(IS)患者不良预后的标记物。研究者旨在评估HbA1C和第一次测量的血糖水平对3个月死亡率的预测能力。

方法:在一项前瞻性分析中,1317名首发IS的患者,按照第一次血糖值分类(低于155,155到199间,大于200mg/dl)。分析非糖尿病的患者,糖尿病但血糖控制(PGC)良好的(HbA1C<7%)患者,糖尿病但血糖控制不好(HbA1C≥7.0%)。

结果:3个月死亡率为13.1%,非糖尿病(DM)患者(12.3%),良好PGC-DM(12.4)与不良PGC-DM(15.6%)患者之间没有差异。血糖≥200mg/dl的非糖尿病患者3个月死亡率的非校正RR值为3.76 (95% CI 1.48-9.56),良好PGC-DM患者的RR值为6.10 (95% CI 1.76-21.09),不良PGC-DM患者的RR值为1.44 (95% CI 0.77-2.69)。血糖的界值点与死亡率升高、PGC下降相关:非糖尿病患者107mg/dl,良好PGC-DM患者152mg/dl,不良PGC-DM患者 229 mg/dl。血糖水平与非糖尿病患者和良好控制的糖尿病患者的卒中严重程度相关,与血糖控制不良的糖尿患者无关。

结论:HbA1C和第一次测量血糖值有助于IS患者的死亡风险分层:高血糖是非糖尿病患者和良好PGC-DM患者不良预后的预测因子;但不能预测不良PGC-DM的患者的预后。研究表明高血糖和不良预后的关系反应的是应激反应而不是血糖的不利因素。

原文出处:

Roquer J, Giralt-Steinhauer E, Cerdà G,et al. Glycated Hemoglobin Value Combined with Initial Glucose Levels for Evaluating Mortality Risk in Patients with Ischemic Stroke. Cerebrovasc Dis. 2015 Oct 21.


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    2016-01-03 quxin068
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    2015-10-23 快乐晴天

    哈哈哈哈哈

    0

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