袁晶：使用CRISPR/Cas9介导的同源重组修复机制编辑疟原虫基因组

2014-09-29 佚名生物谷

9月26日，由生物谷主办的2014基因组编辑研讨会在上海好望角大饭店隆重举行。厦门大学的袁晶教授参加了此次大会并发表了题为"Efficient Editing of Malaria Parasite Genome Using the CRIPR/Cas9 System"的精彩报告。疟疾是由疟原虫属寄生虫感染引起的传染性疾病，全球每年约有数亿人口感染疟疾，其中上百人死亡。基于目前疟原虫对抗疟

9月26日，由生物谷主办的2014基因组编辑研讨会在上海好望角大饭店隆重举行。厦门大学的袁晶教授参加了此次大会并发表了题为"Efficient Editing of Malaria Parasite Genome Using the CRIPR/Cas9 System"的精彩报告。

疟疾是由疟原虫属寄生虫感染引起的传染性疾病，全球每年约有数亿人口感染疟疾，其中上百人死亡。基于目前疟原虫对抗疟药产生抗药性，袁晶教授致力于寻找新的抗疟靶点。袁晶教授在报告中讲到，疟原虫作为一种没有siRNA干扰系统和非同源末端连接修复机制的生物，极大地限制了人类对疟原虫基因功能的揭示。他们对于疟原虫基因组的编辑做了很多尝试，这些尝试都为疟原虫基因组编辑工作的成功积累了宝贵的意见。

之后袁晶教授重点讲述了他们使用CRISPR/Cas9系统将DNA双链断裂引入到疟原虫基因组中的各个技术关键点，他们通过同源重组的修复机制，实现了疟原虫基因组中的多个基因的不同类型修饰，包括基因删除、基因加标签和等位基因替换。他们的工作极大地促进了疟原虫生物学的研究。

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#插入话题

插入图片

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2015-04-29 rebeccajiejie

#RISPR/Cas9#

59 0
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2014-10-18 heli0118

#同源重组#

66 0
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2014-10-01 yuandd

#CRISPR#

76 0
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2014-10-01 haouestc

#CRISPR/Cas9#

60 0
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2014-10-01 respect

#Cas9#

62 0
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2014-10-01 一叶知秋

#疟原虫#

108 0
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2014-10-01 yaanren

#Cas#

114 0

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