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J Periodontol:非手术治疗是否可以减少局部侵袭性牙周炎的JP2

2017-11-23 MedSci MedSci原创

以前的研究已经提供了伴放线放线杆菌和高度破坏白细胞的JP2基因型与局部侵袭性牙周炎(LAgP)关系的实质证据。本研究旨在评估牙周治疗后LAgP患者中JP2的情况。

以前的研究已经提供了伴放线放线杆菌和高度破坏白细胞的JP2基因型与局部侵袭性牙周炎(LAgP)关系的实质证据。本研究旨在评估牙周治疗后LAgP患者中JP2的情况。

方法:检查60例5?25岁的LAgP非裔美国患者。在治疗前,测量探诊深度(PD),临床附着水平(CAL),探查出血和菌斑指数,并且收集每个参与者的LAgP和健康位点的龈下菌斑。患者接受全口腔超声洁治,刮治和根面平整,以及为期7天的阿莫西林和甲硝唑治疗。参与者重新检测和采样,并在治疗后的第3,6和12个月接受定期维持治疗。使用聚合酶链式反应来检测处理之前和之后的JP2基因型。

结果:术前,75%的LAgP位点和56.67%的健康位点可以鉴定出JP2序列。治疗后3,6,12个月,患者数分别为40,31和31,疾病位点JP2检出率分别下降到17.5%,6.45%,3.23%(P <0.001);健康位点分别为2.5%,3.23%和0%(P <0.001)。治疗后临床参数也显着降低(P <0.001)。此外,在治疗后JP2与平均PD(P <0.002)和CAL(P <0.001)之间相关性显着。

结论:牙周治疗能有效减少疾病和健康位点的临床参数和龈下JP2。

原始出处:

Danielle K. Burgess, et al. Non-Surgical Therapy Reduces Presence of JP2 Clone in Localized Aggressive Periodontitis. Journal of Periodontology . 2017 December. doi: 10.1902/jop.2017.170285

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    2018-07-01 feather89
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    2017-11-25 sunyl07
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    2017-11-25 chg122
  5. 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  8. 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    2017-11-25 lyh994

    全口腔超声洁治.刮治和根面平整

    0

  9. 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content=全口腔超声洁治.刮治和根面平整, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sat Nov 25 08:19:24 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264075, encodeId=2e6d2640e5b3, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Sat Nov 25 06:25:21 CST 2017, time=2017-11-25, status=1, ipAttribution=), 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    2017-11-25 chunjianf

    学习了.谢谢分享

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=263902, encodeId=d77826390236, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Nov 24 09:08:26 CST 2017, time=2017-11-24, status=1, ipAttribution=)]
    2017-11-24 yfjms

    学习

    0

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