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JCEM:非肥胖2型糖尿病患者的胰岛素敏感性研究

2016-08-29 Moon 译 MedSci原创

脂肪因子chemerin/二肽基肽酶4(DPP4)和脂联素会对胰岛素敏感性产生影响。不过对于非肥胖2型糖尿病(T2DM)个体,这些物质的循环水平和脂肪分泌是否会发生改变仍是未知的。 因此有研究者进行了研究,调查皮下脂肪分泌和三种血清脂肪因子水平与T2DM特征的联系。 研究纳入了14例非肥胖2型糖尿病患者和13例健康男性使用高胰岛素葡萄糖钳夹试验、稳态模式评估和HbA1c,评估参与者胰岛

脂肪因子chemerin/二肽基肽酶4(DPP4)和脂联素会对胰岛素敏感性产生影响。不过对于非肥胖2型糖尿病(T2DM)个体,这些物质的循环水平和脂肪分泌是否会发生改变仍是未知的。

因此有研究者进行了研究,调查皮下脂肪分泌和三种血清脂肪因子水平与T2DM特征的联系。

研究纳入了14例非肥胖2型糖尿病患者和13例健康男性使用高胰岛素葡萄糖钳夹试验、稳态模式评估和HbA1c,评估参与者胰岛素敏感性/血糖控制情况。

主要结局为循环和脂肪分泌的脂肪因子与脂肪细胞体积和胰岛素敏感性之间的关联。

结果显示,组间脂肪分泌是相似的;T2DM患者有更高的血清chemerin(70±10 vs 50±1 ng/ml; p=0.005)、更低的脂联素水平(4.7±1.3 vs 6.8±2.2 μ g/ml; p=0.005)、DDP4水平不变。血清脂联素(r=0.53; p=0.005)和chemerin (r=-0.42; p=0.03)与脂肪分泌水平相关。分泌和循环中chemerin与脂肪细胞体积呈正相关(r>0.40; p<0.05),不过血清脂联素与脂肪细胞体积呈负相关(r=-0.61; p=0.001)。脂联素血清半衰期在T2DM患者中降低(168±24 vs 186±18 min; p=0.029),与HbA1C (r=-0.45; p=0.03)和脂肪细胞体积(r=-0.56; p<0.003)呈负相关。血清脂联素(r=0.57; p=0.017)和chemerin (r=-0.52; p=0.03)和钳夹试验独立诊断T2DM有关。

结果表明,对于非肥胖男性,T2DM患者的循环中脂联素和chemerin水平改变,但是脂肪分泌没有发生变化。脂肪细胞体积对血清Chemerin和脂联素的变化以及脂联素清除率是十分重要的,更差的血糖控制也对脂联素的清除起一定作用。

原始出处:

Andersson DP.et al.Circulating and adipose levels of adipokines associated with insulin sensitivity in non-obese subjects with type 2 diabetes.J Clin Endocrinol Metab. 2016 Aug 8:jc20161883. [Epub ahead of print]

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    2016-11-27 achengzhao
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    2016-10-20 baoya
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10:06:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474038, encodeId=095e14e403860, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Aug 31 10:06:00 CST 2016, time=2016-08-31, status=1, ipAttribution=)]
  4. 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encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Mon May 15 16:06:00 CST 2017, time=2017-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131618, encodeId=0db113161815, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 20 22:09:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=123895, encodeId=f00c12389529, content=人体很奇妙,慢慢了解其中的奥秘吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Mon Sep 12 19:16:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=109874, encodeId=e4341098e42d, content=学习一下,好, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Fri Sep 02 21:50:00 CST 2016, time=2016-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383244, encodeId=00b41383244bc, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Aug 31 10:06:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388330, encodeId=2e961388330b7, content=<a href='/topic/show?id=7ef25e5346b' target=_blank style='color:#2F92EE;'>#敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJnkE6UvGFfMS41qV0RicWvVTTeLMicqibeZH5GqO4YhNicyl1Y9jFhylIUBn9ntPYy9jhk5hrfic5cRYw/132, createdBy=5f822500020, createdName=ms5236388012055669, createdTime=Wed Aug 31 10:06:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474038, encodeId=095e14e403860, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Aug 31 10:06:00 CST 2016, time=2016-08-31, status=1, ipAttribution=)]
    2017-05-15 smallant2015
  5. 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10:06:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474038, encodeId=095e14e403860, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Aug 31 10:06:00 CST 2016, time=2016-08-31, status=1, ipAttribution=)]
    2016-09-20 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

  6. 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objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Aug 31 10:06:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388330, encodeId=2e961388330b7, content=<a href='/topic/show?id=7ef25e5346b' target=_blank style='color:#2F92EE;'>#敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJnkE6UvGFfMS41qV0RicWvVTTeLMicqibeZH5GqO4YhNicyl1Y9jFhylIUBn9ntPYy9jhk5hrfic5cRYw/132, createdBy=5f822500020, createdName=ms5236388012055669, createdTime=Wed Aug 31 10:06:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474038, encodeId=095e14e403860, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Aug 31 10:06:00 CST 2016, time=2016-08-31, status=1, ipAttribution=)]
    2016-09-12 舒心和人

    人体很奇妙,慢慢了解其中的奥秘吧

    0

  7. 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    2016-09-02 1771ae4158m

    学习一下,好

    0

  8. 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  9. 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