Circ Res：MicroRNA-181b调节TIMP-3和弹性蛋白来调控动脉粥样硬化和动脉瘤

2017-03-20 MedSci MedSci原创

近日，心血管领域权威杂志Circulation Research上发表了一篇研究文章，研究人员探索miR-181b是否通过调节基质金属蛋白酶的组织抑制剂3（TIMP-3）表达而影响动脉粥样硬化和动脉瘤。

动脉粥样硬化和动脉瘤是目前世界上死亡率较高的疾病。MicroRNA（miR）是调控基因和蛋白表达的关键因素且与许多心血管疾病相关。目前对于miR在动脉粥样硬化斑块和腹主动脉瘤稳定性中的作用了解甚少。

近日，心血管领域权威杂志Circulation Research上发表了一篇研究文章，研究人员探索miR-181b是否通过调节基质金属蛋白酶的组织抑制剂3（TIMP-3）表达而影响动脉粥样硬化和动脉瘤。

研究发现miR-181b在人动脉粥样硬化斑块和腹主动脉瘤中高表达，并与TIMP-3和弹性蛋白的表达减少相关。给予Apoe - / - 和Ldlr - / -小鼠动脉粥样硬化模型抗miR-181b处理延迟了动脉粥样硬化斑块的发生发展。给予血管紧张素II+ Apoe - / - 或Ldlr - / - 小鼠抗miR-181b处理减轻了升主动脉、胸腹主动脉内动脉瘤的形成发展。此外抗miR-181b大大增加了弹性蛋白和胶原表达，促进纤维化并稳定斑块和动脉瘤。miR-181b负性调节巨噬细胞TIMP-3和血管平滑肌细胞产生弹性蛋白，而这两者都是维持动脉粥样硬化斑块和动脉瘤稳定的重要因素。在Timp3 - / - 小鼠中验证实验发现，抑制miR-181b得到的有益后果主要是通过TIMP-3和提高弹性蛋白合成。

研究结果表明miR-181b及其靶基因是动脉粥样硬化和动脉瘤稳定性的治疗靶点。

原始出处：Di Gregoli K， Mohamad Anuar NN，et al. MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin. Circ Res. 2017 Jan 6；120(1)：49-65.

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2017-09-07 ZGMFX24A

#TIMP-3#

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2017-04-10 liao1619

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2018-02-21 huangshifeng

#粥样硬化#

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2018-01-25 jiafufeng@yaho

#CRO#

46 0
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2017-08-18 xjy02

#Micro#

42 0
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2017-03-24 虈亣靌

学习新知识谢谢分享

1 0
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2017-03-22 zhouqu_8

#microRNA#

49 0

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